• Author: Riitho, Victor

    UK Department for Environment, Food and Rural Affairs

  • Author: Larska, Magdalena

    Swedish University of Agricultural Sciences

  • Author: Strong, Rebecca

    UK Department for Environment, Food and Rural Affairs

  • Author: La Rocca, S. Anna

    UK Department for Environment, Food and Rural Affairs

  • Author: Locker, Nicolas

    University of Surrey

  • Author: Alenius, Stefan

    Swedish University of Agricultural Sciences

  • Author: Steinbach, Falko

    UK Department for Environment, Food and Rural Affairs

  • Author: Liu, Lihong

    Swedish University of Agricultural Sciences

  • Author: Uttenthal, Åse

    National Veterinary Institute, Technical University of Denmark

  • Author: Graham, Simon P.

    UK Department for Environment, Food and Rural Affairs

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Atypical ruminant pestiviruses are closely related to the two bovine viral diarrhoea virus (BVDV) species, BVDV-1 and BVDV-2. While there is evidence of cross-protective immune responses between BVDV-1 and BVDV-2, despite antigenic differences, there is little information on the antigenic cross-reactivity with atypical ruminant pestiviruses. The aim of this study was therefore to assess the specificity of antibody and T cell responses induced by experimental infection of calves with BVDV-1 strain Ho916, Th/04_KhonKaen (TKK), an Asiatic atypical ruminant pestivirus, or co-infection with both viruses. Homologous virus neutralization was observed in sera from both single virus infected and co-infected groups, while cross-neutralization was only observed in the TKK infected group. T cell IFN-γ responses to both viruses were observed in the TKK infected animals, whereas Ho916 infected calves responded better to homologous virus. Specifically, IFN-γ responses to viral non-structural protein, NS3, were observed in all infected groups while responses to viral glycoprotein, E2, were virus-specific. Broader antigen-specific cytokine responses were observed with similar trends between inoculation groups and virus species. The limited T cell and antibody immune reactivity of Ho916 inoculated animals to TKK suggests that animals vaccinated with current BVDV-1-based vaccines may not be protected against atypical ruminant pestiviruses.

Original languageEnglish
JournalVaccine
Volume36
Issue number30
Pages (from-to)4494–4500
ISSN0264-410X
DOIs
StatePublished - 2018
CitationsWeb of Science® Times Cited: 0

    Research areas

  • Atypical pestivirus, BVDV, Cross-reactivity, Immune responses
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