Classification of parasite eggs used as an active pharmaceutical ingredient (API)

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Standard

Classification of parasite eggs used as an active pharmaceutical ingredient (API). / Bruun, J. M.; Carstensen, Jens Michael; Thamsborg, S.; Roepstorff, A.; Christensen, S. ; Kapel, C. M. O.

Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology, 2012. p. 7.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Harvard

Bruun, JM, Carstensen, JM, Thamsborg, S, Roepstorff, A, Christensen, S & Kapel, CMO 2012, 'Classification of parasite eggs used as an active pharmaceutical ingredient (API)'. in Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology, pp. 7.

APA

Bruun, J. M., Carstensen, J. M., Thamsborg, S., Roepstorff, A., Christensen, S., & Kapel, C. M. O. (2012). Classification of parasite eggs used as an active pharmaceutical ingredient (API). In Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. (pp. 7). Danish Society for Parasitology.

CBE

Bruun JM, Carstensen JM, Thamsborg S, Roepstorff A, Christensen S, Kapel CMO. 2012. Classification of parasite eggs used as an active pharmaceutical ingredient (API). In Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology. pp. 7.

MLA

Bruun, J. M. et al. "Classification of parasite eggs used as an active pharmaceutical ingredient (API)". Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology. 2012. 7.

Vancouver

Bruun JM, Carstensen JM, Thamsborg S, Roepstorff A, Christensen S, Kapel CMO. Classification of parasite eggs used as an active pharmaceutical ingredient (API). In Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology. 2012. p. 7.

Author

Bruun, J. M.; Carstensen, Jens Michael; Thamsborg, S.; Roepstorff, A.; Christensen, S. ; Kapel, C. M. O. / Classification of parasite eggs used as an active pharmaceutical ingredient (API).

Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society: Danish Society for Parasitology and Danish Society for Tropical Medicine & International Health. Danish Society for Parasitology, 2012. p. 7.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Bibtex

@inbook{5289eb5af5504c8a8357bf64a833cad2,
title = "Classification of parasite eggs used as an active pharmaceutical ingredient (API)",
publisher = "Danish Society for Parasitology",
author = "Bruun, {J. M.} and Carstensen, {Jens Michael} and S. Thamsborg and A. Roepstorff and S. Christensen and Kapel, {C. M. O.}",
year = "2012",
pages = "7",
booktitle = "Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society",

}

RIS

TY - ABST

T1 - Classification of parasite eggs used as an active pharmaceutical ingredient (API)

A1 - Bruun,J. M.

A1 - Carstensen,Jens Michael

A1 - Thamsborg,S.

A1 - Roepstorff,A.

A1 - Christensen,S.

A1 - Kapel,C. M. O.

AU - Bruun,J. M.

AU - Carstensen,Jens Michael

AU - Thamsborg,S.

AU - Roepstorff,A.

AU - Christensen,S.

AU - Kapel,C. M. O.

PB - Danish Society for Parasitology

PY - 2012

Y1 - 2012

N2 - The aim of the project is to describe the developmental stages of parasite eggs using digital image analysis of multispectral imagery. The primary focus is to identify and count eggs of different developmental stages and distinguish them from unrelated particles. This information is used to assess the pharmaceutical potency of eggs from the parasite Trichuris suis (pig whipworm), used as an active pharmaceutical ingredient in medicine against chronic autoimmune diseases of the intestines such as Crohn's disease and Ulcerative colitis. The analysis will combine spectral and morphological characteristics in order to first detect and then classify the parasite eggs based on a set of biologically inspired, quantitative features. The egg classification is currently done manually using transmitted light microscopy, but to allow for validation of this process and to reduce the operator bias, an automated system is being developed. The developed procedure should be robust, non-invasive and fast, and could potentially have applications in description of other organisms. An initial analysis was carried out as a proof of concept. The detection of embryonated eggs was done using matched filtering and the classification was based on the orientation of the larva inside the egg: The ratio of longitudinal vs. latitudinal ‘lines’ inside the egg is higher for eggs containing a larva.

AB - The aim of the project is to describe the developmental stages of parasite eggs using digital image analysis of multispectral imagery. The primary focus is to identify and count eggs of different developmental stages and distinguish them from unrelated particles. This information is used to assess the pharmaceutical potency of eggs from the parasite Trichuris suis (pig whipworm), used as an active pharmaceutical ingredient in medicine against chronic autoimmune diseases of the intestines such as Crohn's disease and Ulcerative colitis. The analysis will combine spectral and morphological characteristics in order to first detect and then classify the parasite eggs based on a set of biologically inspired, quantitative features. The egg classification is currently done manually using transmitted light microscopy, but to allow for validation of this process and to reduce the operator bias, an automated system is being developed. The developed procedure should be robust, non-invasive and fast, and could potentially have applications in description of other organisms. An initial analysis was carried out as a proof of concept. The detection of embryonated eggs was done using matched filtering and the classification was based on the orientation of the larva inside the egg: The ratio of longitudinal vs. latitudinal ‘lines’ inside the egg is higher for eggs containing a larva.

UR - http://parasitology.dk/web/media/Spring%20symposium%20-%20program%20and%20abstracts/Abstracts%20Spring%20Symposium%202012.pdf

BT - Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society

T2 - Joint Spring Symposium 2012 - Double burden of disease – how parasites interact with each other, their host and the society

SP - 7

ER -