Choosing the right platform for the right product: Sustainable production of chemicals in microbial cell factories

Publication: Research - peer-reviewConference abstract for conference – Annual report year: 2012

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The Novo Nordisk Foundation Center for Biosustainability (CFB) is a new non-profit research center focused on sustainable production of biochemicals and therapeutic proteins using microbial and mammalian cell factories. The work at CFB is organized around an iterative loop where cell factories are taken through four stages: 1) In silico design and data analysis, 2) genome engineering, 3) characterization and high throughput screening, and 4) omics based systems analysis. However, before entering this loop, significant two significant decisions need to be made. First, the choice of what products should be made should be made considering biological, technical, economic, and ecological factors. Second, the choice which platform strains will be used to develop production hosts should be made based on characterization of both metabolic and process tolerance traits of strains. I will discuss the role of modeling and systems biology approaches in guiding both the product and strain selection processes.
Original languageEnglish
Publication date2012
StatePublished

Conference

ConferenceChemical engineering at the Life science interface conference
CountryUnited Kingdom
CitySheffield
Period12/11/12 → …

Bibliographical note

Markus Herrgard
Conference presentation at
Chemical Engineering at the Life Science Interface Conference Sheffield, UK
November 12, 2012

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