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  • Author: Basic, D.

    Norwegian School of Veterinary Science, Norway

  • Author: Schjolden, J.

    Norwegian School of Veterinary Science, Norway

  • Author: Krogdahl, A.

    Norwegian School of Veterinary Science, Norway

  • Author: von Krogh, K.

    Norwegian School of Veterinary Science, Norway

  • Author: Hillestad, M.

    BioMar, Norway

  • Author: Winberg, S.

    Uppsala University, Sweden

  • Author: Mayer, I.

    Norwegian School of Veterinary Science, Norway

  • Author: Skjerve, E.

    Norwegian School of Veterinary Science, Norway

  • Author: Höglund, Erik

    Section for Aquaculture, National Institute of Aquatic Resources, Technical University of Denmark, Nordsøen Forskerpark Postboks 101, 9850, Hirtshals, Denmark

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The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with l-tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod (Gadus morhua) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response

Original languageEnglish
JournalBritish Journal of Nutrition
Publication date2013
Volume109
Issue12
Pages2166-2174
ISSN0007-1145
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 1
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