• Author: Blinkenberg, Morten

    Copenhagen University Hospital

  • Author: Mathiesen, Henrik K

    Copenhagen University Hospital

  • Author: Tscherning, Thomas

    Copenhagen University Hospital

  • Author: Jønsson, Agnete

    Copenhagen University Hospital

  • Author: Svarer, Claus

    Copenhagen University Hospital

  • Author: Holm, Søren

    Copenhagen University Hospital

  • Author: Sellebjerg, Finn

    Copenhagen University Hospital

  • Author: Paulson, Olaf B

    Copenhagen University Hospital

  • Author: Hanson, Lars G.

    Department of Electrical Engineering, Technical University of Denmark, Hvidovre Hospital, Denmark

  • Author: Sorensen, Per S

    Copenhagen University Hospital

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OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients. Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P
Original languageEnglish
JournalNeurological research.
Publication date2012
Volume34
Issue1
Pages52-58
ISSN01616412
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 4
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