CD103+ CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin
Research output: Research - peer-review › Journal article – Annual report year: 2018
Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+ CD11b+(DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+ CD11b- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β 7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.
Original language | English |
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Journal | Mucosal Immunology |
Volume | 11 |
Issue number | 3 |
Pages (from-to) | 681-692 |
ISSN | 1933-0219 |
DOIs | |
State | Published - 1 May 2018 |
Citations | Web of Science® Times Cited: 2 |
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