Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells
Publication: Research - peer-review › Journal article – Annual report year: 2012
Without internal affiliation
Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through
cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand,
are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system,
inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The
advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system,
thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is
expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated
with the liposomes.
Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)
Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)
Original language | English |
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Journal | Journal of Controlled Release |
ISSN | 0168-3659 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Citations | Web of Science® Times Cited: 44 |
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