Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Without internal affiliation

  • Author: Karchemski, Faina

    Ben-Gurion University of the Negev, Department of Chemical Engineering

  • Author: Zucker, Daniel

    Unknown

  • Author: Barenholz, Yechezkel

    The Hebrew University-Hadassah Medical School, Department of Biochemistry

  • Author: Regev, Oren

    Ben-Gurion University of the Negev, Department of Chemical Engineering

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Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system, inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated with the liposomes.
Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)
Original languageEnglish
JournalJournal of Controlled Release
Publication date2012
ISSN0168-3659
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 20
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