Cantilever-based micro-particle filter with simultaneous single particle detection

Publication: Research - peer-reviewJournal article – Annual report year: 2011

View graph of relations

Currently, separation of whole blood samples on lab-on-a-chip systems is achieved via filters followed by analysis of the filtered matter such as counting of blood cells. Here, a micro-chip based on cantilever technology is developed, which enables simultaneous filtration and counting of micro-particles from a liquid. A hole-array is integrated into a micro-cantilever, which is inserted into a microfluidic channel perpendicular to the flow. A metal pad at the apex of the cantilever enables an optical read-out of the deflection of the cantilever. When a micro-particle is too large to pass a hole in the cantilever, clogging of the holes increases the flow resistance of the cantilever. This causes a bending of the device, which can be detected by the optical read-out system. By arranging an array of such cantilevers with different hole sizes, separation by size can be achieved. In this paper a proof of concept of the device is demonstrated by filtering and counting 20 mu m polystyrene beads dispersed in an aqueous solution.
Original languageEnglish
JournalJournal of Micromechanics and Microengineering
Publication date2011
Volume21
Issue5
ISSN0960-1317
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 3

Keywords

  • Filters, Physiological materials (e.g. blood, collagen, etc.), Fluidics, Tissue engineering, Flow phenomena in quasi-one-dimensional systems
Download as:
Download as PDF
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
Word

ID: 5713726