Calibrated mitotic oscillator drives motile ciliogenesis

Publication: Research - peer-reviewJournal article – Annual report year: 2017

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  • Author: Al Jord, Adel

    Paris Sciences et Lettres

  • Author: Shihavuddin, Asm

    PSL Research University

  • Author: D’Aout, Raphaël Servignat

    Paris Sciences et Lettres

  • Author: Faucourt, Marion

    Paris Sciences et Lettres

  • Author: Genovesio, Auguste

    Paris Sciences et Lettres

  • Author: Karaiskou, Anthi

    Universite Paris Sorbonne - Paris IV

  • Author: Sobczak-Thépot, Joëlle

    Universite Paris Sorbonne - Paris IV

  • Author: Spassky, Nathalie

    Paris Sciences et Lettres

  • Author: Meunier, Alice

    Paris Sciences et Lettres

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Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase 1–anaphase-promoting complex/cyclosome (CDK1-APC/C) axis, spatiotemporally coordinates this reorganization in dividing cells. Here we discovered that nondividing cells could also implement this mitotic clocklike regulatory circuit to orchestrate subcellular reorganization associated with differentiation. We probed centriole amplification in differentiating mouse-brain multiciliated cells. These postmitotic progenitors fine-tuned mitotic oscillator activity to drive the orderly progression of centriole production, maturation, and motile ciliation while avoiding the mitosis commitment threshold. Insufficient CDK1 activity hindered differentiation, whereas excessive activity accelerated differentiation yet drove postmitotic progenitors into mitosis. Thus, postmitotic cells can redeploy and calibrate the mitotic oscillator to uncouple cytoplasmic from nuclear dynamics for organelle remodeling associated with differentiation.

Original languageEnglish
JournalScience
Volume358
Issue number6364
Pages (from-to)803-806
Number of pages4
ISSN0036-8075
DOIs
StatePublished - 10 Nov 2017
Externally publishedYes
CitationsWeb of Science® Times Cited: 2
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