Bubble coalescence in breathing DNA: Two vicious walkers in opposite potentials

Publication: Research - peer-reviewJournal article – Annual report year: 2007

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We investigate the coalescence of two DNA bubbles initially located at weak segments and separated by a more stable barrier region in a designed construct of double-stranded DNA. The characteristic time for bubble coalescence and the corresponding distribution are derived, as well as the distribution of coalescence positions along the barrier. Below the melting temperature, we find a Kramers-type barrier crossing behaviour, while at high temperatures, the bubble corners perform drift-diffusion towards coalescence. The results are obtained by mapping the bubble dynamics on the problem of two vicious walkers in opposite potentials.
Original languageEnglish
JournalEurophysics Letters
Publication date2007
Volume77
Pages48001
ISSN0295-5075
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 12
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