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Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates. Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6). OPN enrichment decreased NEC severity relative to control formula (P
Original languageEnglish
JournalBritish Journal of Nutrition
Publication date2011
Volume105
Issue1
Pages44-53
ISSN0007-1145
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 18

Keywords

  • Necrotising enterocolitis, Milk bioactives, Colostrum, Immunomodulation
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