Biomimetic Membrane Arrays on Cast Hydrogel Supports

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Biomimetic Membrane Arrays on Cast Hydrogel Supports. / Roerdink-Lander, Monique; Ibragimova, Sania; Rein Hansen, Christian; Vogel, Jörg; Jensen, Karin Bagger Stibius; Geschke, Oliver; Perry, Mark; Helix Nielsen, Claus.

In: Langmuir, Vol. 27, No. 11, 2011, p. 7002-7007.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Roerdink-Lander, Monique; Ibragimova, Sania; Rein Hansen, Christian; Vogel, Jörg; Jensen, Karin Bagger Stibius; Geschke, Oliver; Perry, Mark; Helix Nielsen, Claus / Biomimetic Membrane Arrays on Cast Hydrogel Supports.

In: Langmuir, Vol. 27, No. 11, 2011, p. 7002-7007.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{314828db7ab44d608b74a4de15431ae9,
title = "Biomimetic Membrane Arrays on Cast Hydrogel Supports",
publisher = "American Chemical Society",
author = "Monique Roerdink-Lander and Sania Ibragimova and {Rein Hansen}, Christian and Jörg Vogel and Jensen, {Karin Bagger Stibius} and Oliver Geschke and Mark Perry and {Helix Nielsen}, Claus",
year = "2011",
doi = "10.1021/la1050699",
volume = "27",
number = "11",
pages = "7002--7007",
journal = "Langmuir",
issn = "0743-7463",

}

RIS

TY - JOUR

T1 - Biomimetic Membrane Arrays on Cast Hydrogel Supports

A1 - Roerdink-Lander,Monique

A1 - Ibragimova,Sania

A1 - Rein Hansen,Christian

A1 - Vogel,Jörg

A1 - Jensen,Karin Bagger Stibius

A1 - Geschke,Oliver

A1 - Perry,Mark

A1 - Helix Nielsen,Claus

AU - Roerdink-Lander,Monique

AU - Ibragimova,Sania

AU - Rein Hansen,Christian

AU - Vogel,Jörg

AU - Jensen,Karin Bagger Stibius

AU - Geschke,Oliver

AU - Perry,Mark

AU - Helix Nielsen,Claus

PB - American Chemical Society

PY - 2011

Y1 - 2011

N2 - Lipid bilayers are intrinsically fragile and require mechanical support in technical applications based on biomimetic membranes. Tethering the lipid bilayer membranes to solid substrates, either directly through covalent or ionic substrate−lipid links or indirectly on substrate-supported cushions, provides mechanical support but at the cost of small molecule transport through the membrane−support sandwich. To stabilize biomimetic membranes while allowing transport through a membrane−support sandwich, we have investigated the feasibility of using an ethylene tetrafluoroethylene (ETFE)/hydrogel sandwich as the support. The sandwich is realized as a perforated surface-treated ETFE film onto which a hydrogel composite support structure is cast. We report a simple method to prepare arrays of lipid bilayer membranes with low intrinsic electrical conductance on the highly permeable, self-supporting ETFE/hydrogel sandwiches. We demonstrate how the ETFE/hydrogel sandwich support promotes rapid self-thinning of lipid bilayers suitable for hosting membrane-spanning proteins.

AB - Lipid bilayers are intrinsically fragile and require mechanical support in technical applications based on biomimetic membranes. Tethering the lipid bilayer membranes to solid substrates, either directly through covalent or ionic substrate−lipid links or indirectly on substrate-supported cushions, provides mechanical support but at the cost of small molecule transport through the membrane−support sandwich. To stabilize biomimetic membranes while allowing transport through a membrane−support sandwich, we have investigated the feasibility of using an ethylene tetrafluoroethylene (ETFE)/hydrogel sandwich as the support. The sandwich is realized as a perforated surface-treated ETFE film onto which a hydrogel composite support structure is cast. We report a simple method to prepare arrays of lipid bilayer membranes with low intrinsic electrical conductance on the highly permeable, self-supporting ETFE/hydrogel sandwiches. We demonstrate how the ETFE/hydrogel sandwich support promotes rapid self-thinning of lipid bilayers suitable for hosting membrane-spanning proteins.

U2 - 10.1021/la1050699

DO - 10.1021/la1050699

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 11

VL - 27

SP - 7002

EP - 7007

ER -