Biologically Active Macrocyclic Compounds – from Natural Products to Diversity‐Oriented Synthesis

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Macrocyclic compounds are attractive targets when searching for molecules with biological activity. The interest in this compound class is increasing, which has led to a variety of methods for tackling the difficult macrocyclization step in their synthesis. This microreview highlights some recent developments in the synthesis of macrocycles, with an emphasis on chemistry developed to generate libraries of putative biologically active compounds.
Original languageEnglish
JournalEuropean Journal of Organic Chemistry
Volume2011
Issue number17
Pages (from-to)3107-3115
ISSN1434-193X
DOIs
StatePublished - 2011
Peer-reviewedYes
CitationsWeb of Science® Times Cited: 27

Keywords

  • Synthetic methods, Macrocyclization, Natural products, Diversity-oriented synthesis, Biological activity
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