Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens. / Hisham Beshara Halasa, Tariq.

In: Journal of Dairy Science, Vol. 95, No. 10, 2012, p. 5740-5749.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Hisham Beshara Halasa, Tariq / Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens.

In: Journal of Dairy Science, Vol. 95, No. 10, 2012, p. 5740-5749.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{c2db91efe7f74d9a88bae7a637cd2743,
title = "Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens",
keywords = "Clinical mastitis, Treatment, Economic model, Transmission",
publisher = "American Dairy Science Association",
author = "{Hisham Beshara Halasa}, Tariq",
year = "2012",
doi = "10.3168/jds.2012-5470",
volume = "95",
number = "10",
pages = "5740--5749",
journal = "Journal of Dairy Science",
issn = "0022-0302",

}

RIS

TY - JOUR

T1 - Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens

A1 - Hisham Beshara Halasa,Tariq

AU - Hisham Beshara Halasa,Tariq

PB - American Dairy Science Association

PY - 2012

Y1 - 2012

N2 - The objective of this study was to assess the epidemiologic and economic consequences of intervention against contagious clinical mastitis during lactation. A bioeconomic model of intramammary infections (IMI) was used to simulate contagious spread of Staphylococcus aureus, Streptococcus uberis, and Streptococcus dysgalactiae, and an environmental spread of Escherichia coli IMI in a 100-cow dairy herd during 1 quota year. The costs of clinical IMI, subclinical IMI, and intervention were calculated into the total annual net costs of IMI during lactation per scenario and compared with a default scenario. Input parameter values were based on the scientific literature. The scenarios were 3-d intramammary lactational treatment (default), 5-d intramammary treatment, 5-d intramammary treatment and 3-d systemic treatment, 3-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows, and 5-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows. Sensitivity analysis was conducted on parameter input values. The results showed that interventions including antibiotic treatment combined with culling unrecovered clinical IMI cows resulted in the lowest transmission, number of IMI cases, and persistent subclinical IMI cases. Nonetheless, the high associated costs of culling bacteriologically unrecovered clinical IMI cows made the other scenarios with a long and intensive antibiotic treatment, but without culling, the most cost effective. The model was sensitive to changes to the cure rate of clinical IMI following treatment, but the ranking of the intervention scenarios did not change. The model was most sensitive to the changes to the transmission rate of Staph. aureus. The ranking of the intervention scenarios changed at low transmission rate of this pathogen, in which the default scenario became the most cost-effective scenario. In case of high transmission of contagious IMI pathogens, long and intensive treatment of clinical IMI should be preceded by strategies that lower the transmission.

AB - The objective of this study was to assess the epidemiologic and economic consequences of intervention against contagious clinical mastitis during lactation. A bioeconomic model of intramammary infections (IMI) was used to simulate contagious spread of Staphylococcus aureus, Streptococcus uberis, and Streptococcus dysgalactiae, and an environmental spread of Escherichia coli IMI in a 100-cow dairy herd during 1 quota year. The costs of clinical IMI, subclinical IMI, and intervention were calculated into the total annual net costs of IMI during lactation per scenario and compared with a default scenario. Input parameter values were based on the scientific literature. The scenarios were 3-d intramammary lactational treatment (default), 5-d intramammary treatment, 5-d intramammary treatment and 3-d systemic treatment, 3-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows, and 5-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows. Sensitivity analysis was conducted on parameter input values. The results showed that interventions including antibiotic treatment combined with culling unrecovered clinical IMI cows resulted in the lowest transmission, number of IMI cases, and persistent subclinical IMI cases. Nonetheless, the high associated costs of culling bacteriologically unrecovered clinical IMI cows made the other scenarios with a long and intensive antibiotic treatment, but without culling, the most cost effective. The model was sensitive to changes to the cure rate of clinical IMI following treatment, but the ranking of the intervention scenarios did not change. The model was most sensitive to the changes to the transmission rate of Staph. aureus. The ranking of the intervention scenarios changed at low transmission rate of this pathogen, in which the default scenario became the most cost-effective scenario. In case of high transmission of contagious IMI pathogens, long and intensive treatment of clinical IMI should be preceded by strategies that lower the transmission.

KW - Clinical mastitis

KW - Treatment

KW - Economic model

KW - Transmission

U2 - 10.3168/jds.2012-5470

DO - 10.3168/jds.2012-5470

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

IS - 10

VL - 95

SP - 5740

EP - 5749

ER -