Binary toxin and death after Clostridium difficile infection

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Without internal affiliation

Standard

Binary toxin and death after Clostridium difficile infection. / Bacci, S.; Mølbak, K.; Kjeldsen, Marianne Kirstine; Olsen, K. E. P.

In: Emerging Infectious Diseases (Print Edition), Vol. 17, No. 6, 2011.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Harvard

APA

CBE

MLA

Vancouver

Author

Bacci, S.; Mølbak, K.; Kjeldsen, Marianne Kirstine; Olsen, K. E. P. / Binary toxin and death after Clostridium difficile infection.

In: Emerging Infectious Diseases (Print Edition), Vol. 17, No. 6, 2011.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{1b41969754b543eaa8aa85f44274a814,
title = "Binary toxin and death after Clostridium difficile infection",
publisher = "U.S. Department of Health and Human Services Centers for Disease Control and Prevention",
author = "S. Bacci and K. Mølbak and Kjeldsen, {Marianne Kirstine} and Olsen, {K. E. P.}",
year = "2011",
volume = "17",
number = "6",
journal = "Emerging Infectious Diseases (Print Edition)",
issn = "1080-6040",

}

RIS

TY - JOUR

T1 - Binary toxin and death after Clostridium difficile infection

A1 - Bacci,S.

A1 - Mølbak,K.

A1 - Kjeldsen,Marianne Kirstine

A1 - Olsen,K. E. P.

AU - Bacci,S.

AU - Mølbak,K.

AU - Kjeldsen,Marianne Kirstine

AU - Olsen,K. E. P.

PB - U.S. Department of Health and Human Services Centers for Disease Control and Prevention

PY - 2011

Y1 - 2011

N2 - This study compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk (RR) 1.8, 95% confidence interval (CI) 1.2–2.7) and multivariate analysis after adjustment for age, sex and geographic region (RR 1.6, 95% CI 1.0–2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.

AB - This study compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk (RR) 1.8, 95% confidence interval (CI) 1.2–2.7) and multivariate analysis after adjustment for age, sex and geographic region (RR 1.6, 95% CI 1.0–2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.

JO - Emerging Infectious Diseases (Print Edition)

JF - Emerging Infectious Diseases (Print Edition)

SN - 1080-6040

IS - 6

VL - 17

ER -