Binary toxin and death after Clostridium difficile infection
Publication: Research - peer-review › Journal article – Annual report year: 2011
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Binary toxin and death after Clostridium difficile infection. / Bacci, S.; Mølbak, K.; Kjeldsen, Marianne Kirstine; Olsen, K. E. P.
In: Emerging Infectious Diseases (Print Edition), Vol. 17, No. 6, 2011.Publication: Research - peer-review › Journal article – Annual report year: 2011
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TY - JOUR
T1 - Binary toxin and death after Clostridium difficile infection
A1 - Bacci,S.
A1 - Mølbak,K.
A1 - Kjeldsen,Marianne Kirstine
A1 - Olsen,K. E. P.
AU - Bacci,S.
AU - Mølbak,K.
AU - Kjeldsen,Marianne Kirstine
AU - Olsen,K. E. P.
PB - U.S. Department of Health and Human Services Centers for Disease Control and Prevention
PY - 2011
Y1 - 2011
N2 - This study compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk (RR) 1.8, 95% confidence interval (CI) 1.2–2.7) and multivariate analysis after adjustment for age, sex and geographic region (RR 1.6, 95% CI 1.0–2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.
AB - This study compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk (RR) 1.8, 95% confidence interval (CI) 1.2–2.7) and multivariate analysis after adjustment for age, sex and geographic region (RR 1.6, 95% CI 1.0–2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.
JO - Emerging Infectious Diseases (Print Edition)
JF - Emerging Infectious Diseases (Print Edition)
SN - 1080-6040
IS - 6
VL - 17
ER -