Autofluorescence of pigmented skin lesions using a pulsed UV laser with synchronized detection: clinical results

Publication: Research - peer-reviewConference article – Annual report year: 2010

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We report preliminary clinical results of autofluorescence imaging of malignant and benign skin lesions, using pulsed 355 nm laser excitation with synchronized detection. The novel synchronized detection system allows high signal-to-noise ratio to be achieved in the resulting autofluorescence signal, which may in turn produce high contrast images that improve diagnosis, even in the presence of ambient room light. The synchronized set-up utilizes a compact, diode pumped, pulsed UV laser at 355 nm which is coupled to a CCD camera and a liquid crystal tunable filter. The excitation and image capture is sampled at 5 kHz and the resulting autofluorescence is captured with the liquid crystal filter cycling through seven wavelengths between 420 nm and 580 nm. The clinical study targets pigmented skin lesions and evaluates the prospects of using autofluorescence as a possible means in differentiating malignant and benign skin tumors. Up to now, sixteen patients have participated in the clinical study. The autofluorescence images, averaged over the exposure time of one second, will be presented along with histopathological results. Initial survey of the images show good contrast and diagnostic results show promising agreement based on the histopathological results.
Original languageEnglish
JournalProceedings of SPIE, the International Society for Optical Engineering
Publication date2010
Volume7715
Pages77151K
ISSN0277-786X
DOIs
StatePublished

Conference

ConferencePhotonics Europe : Biophotonics: Photonic Solutions for Better Health Care II
CityBrussels, Belgium
Period01/01/10 → …
CitationsWeb of Science® Times Cited: 0
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