Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures. / Krysiak-Baltyn, Konrad; Toppari, J.; Skakkebaek, N. E.; Jensen, Thomas Skøt; Virtanen, H. E.; Schramm, K.‐W.; Shen, Hao; Vartiainen, T.; Kiviranta, H.; Taboureau, Olivier ; Audouze, Karine Marie Laure; Brunak, S.; Main, K. M.

In: International Journal of Andrology, Vol. 35, No. 3, 2012, p. 294-302.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Krysiak-Baltyn, Konrad; Toppari, J.; Skakkebaek, N. E.; Jensen, Thomas Skøt; Virtanen, H. E.; Schramm, K.‐W.; Shen, Hao; Vartiainen, T.; Kiviranta, H.; Taboureau, Olivier ; Audouze, Karine Marie Laure; Brunak, S.; Main, K. M. / Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures.

In: International Journal of Andrology, Vol. 35, No. 3, 2012, p. 294-302.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{e9e079823a674cb5bb69739ec05a5a12,
title = "Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures",
publisher = "Wiley-Blackwell Publishing Ltd.",
author = "Konrad Krysiak-Baltyn and J. Toppari and Skakkebaek, {N. E.} and Jensen, {Thomas Skøt} and Virtanen, {H. E.} and K.‐W. Schramm and Hao Shen and T. Vartiainen and H. Kiviranta and Olivier Taboureau and Audouze, {Karine Marie Laure} and S. Brunak and Main, {K. M.}",
year = "2012",
doi = "10.1111/j.1365-2605.2012.01268.x",
volume = "35",
number = "3",
pages = "294--302",
journal = "International Journal of Andrology",
issn = "0105-6263",

}

RIS

TY - JOUR

T1 - Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures

A1 - Krysiak-Baltyn,Konrad

A1 - Toppari,J.

A1 - Skakkebaek,N. E.

A1 - Jensen,Thomas Skøt

A1 - Virtanen,H. E.

A1 - Schramm,K.‐W.

A1 - Shen,Hao

A1 - Vartiainen,T.

A1 - Kiviranta,H.

A1 - Taboureau,Olivier

A1 - Audouze,Karine Marie Laure

A1 - Brunak,S.

A1 - Main,K. M.

AU - Krysiak-Baltyn,Konrad

AU - Toppari,J.

AU - Skakkebaek,N. E.

AU - Jensen,Thomas Skøt

AU - Virtanen,H. E.

AU - Schramm,K.‐W.

AU - Shen,Hao

AU - Vartiainen,T.

AU - Kiviranta,H.

AU - Taboureau,Olivier

AU - Audouze,Karine Marie Laure

AU - Brunak,S.

AU - Main,K. M.

PB - Wiley-Blackwell Publishing Ltd.

PY - 2012

Y1 - 2012

N2 - During the past four decades, there has been an increase in the incidence rate of male reproductive disorders in some, but not all, Western countries. The observed increase in the prevalence of male reproductive disorders is suspected to be ascribable to environmental factors as the increase has been too rapid to be explained by genetics alone. To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or known endocrine disrupting properties in 130 breast milk samples from Danish and Finnish mothers. Half the newborns were healthy controls, whereas the other half was boys with congenital cryptorchidism. The measured chemicals included polychlorinated biphenyls (PCBs), polybrominated diphenyl‐ethers, dioxins (OCDD/PCDFs), phthalates, polybrominated biphenyls and organochlorine pesticides. Computational analysis of the data was performed using logistic regression and three multivariate machine learning classifiers. Furthermore, we performed systems biology analysis to explore the chemical influence on a molecular level. After correction for multiple testing, exposure to nine chemicals was significantly different between the cases and controls in the Danish cohort, but not in the Finnish cohort. The multivariate analysis indicated that Danish samples exhibited a stronger correlation between chemical exposure patterns in breast milk and cryptorchidism than Finnish samples. Moreover, PCBs were indicated as having a protective effect within the Danish cohort, which was supported by molecular data recovered through systems biology. Our results lend further support to the hypothesis that the mixture of environmental chemicals may contribute to observed adverse trends in male reproductive health.

AB - During the past four decades, there has been an increase in the incidence rate of male reproductive disorders in some, but not all, Western countries. The observed increase in the prevalence of male reproductive disorders is suspected to be ascribable to environmental factors as the increase has been too rapid to be explained by genetics alone. To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or known endocrine disrupting properties in 130 breast milk samples from Danish and Finnish mothers. Half the newborns were healthy controls, whereas the other half was boys with congenital cryptorchidism. The measured chemicals included polychlorinated biphenyls (PCBs), polybrominated diphenyl‐ethers, dioxins (OCDD/PCDFs), phthalates, polybrominated biphenyls and organochlorine pesticides. Computational analysis of the data was performed using logistic regression and three multivariate machine learning classifiers. Furthermore, we performed systems biology analysis to explore the chemical influence on a molecular level. After correction for multiple testing, exposure to nine chemicals was significantly different between the cases and controls in the Danish cohort, but not in the Finnish cohort. The multivariate analysis indicated that Danish samples exhibited a stronger correlation between chemical exposure patterns in breast milk and cryptorchidism than Finnish samples. Moreover, PCBs were indicated as having a protective effect within the Danish cohort, which was supported by molecular data recovered through systems biology. Our results lend further support to the hypothesis that the mixture of environmental chemicals may contribute to observed adverse trends in male reproductive health.

U2 - 10.1111/j.1365-2605.2012.01268.x

DO - 10.1111/j.1365-2605.2012.01268.x

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

IS - 3

VL - 35

SP - 294

EP - 302

ER -