Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves. / Nielsen, Katrine T.; Nielsen, Søren S.; Agger, Jens F.; Christoffersen, Anna-Bodil; Agerholm, Jørgen S.

In: Acta Veterinaria Scandinavica (Print), Vol. 53, 2011, p. 64.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Nielsen, Katrine T.; Nielsen, Søren S.; Agger, Jens F.; Christoffersen, Anna-Bodil; Agerholm, Jørgen S. / Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves.

In: Acta Veterinaria Scandinavica (Print), Vol. 53, 2011, p. 64.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{f8e3bf3c28244f48b995b237cb8f1167,
title = "Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves",
publisher = "Biomed Central Ltd",
author = "Nielsen, {Katrine T.} and Nielsen, {Søren S.} and Agger, {Jens F.} and Anna-Bodil Christoffersen and Agerholm, {Jørgen S.}",
note = "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2011",
doi = "10.1186/1751-0147-53-64",
volume = "53",
pages = "64",
journal = "Acta Veterinaria Scandinavica (Print)",
issn = "0044-605X",

}

RIS

TY - JOUR

T1 - Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves

A1 - Nielsen,Katrine T.

A1 - Nielsen,Søren S.

A1 - Agger,Jens F.

A1 - Christoffersen,Anna-Bodil

A1 - Agerholm,Jørgen S.

AU - Nielsen,Katrine T.

AU - Nielsen,Søren S.

AU - Agger,Jens F.

AU - Christoffersen,Anna-Bodil

AU - Agerholm,Jørgen S.

PB - Biomed Central Ltd

PY - 2011

Y1 - 2011

N2 - Background: Coxiella burnetii is a well-known cause of placentitis and subsequent abortion in ruminants, but there are no reports on the relationship with perinatal mortality. The study was performed to determine the influence of level and change of bulk tank milk (BTM) antibodies to C. burnetii on two outcomes associated with parturition in cattle: a) stillbirth; and b) stillbirth and neonatal mortality combined (perinatal death). Methods: Twenty-four Danish dairy herds were tested repeatedly for antibodies to C. burnetii in BTM using a commercial ELISA. Samples were collected monthly from July 2008 to July 2009. Information on the 2,362 calvings occurring in the study period was obtained from the Danish Cattle Database. Two multilevel logistic regression models were created for the two outcomes stillbirth and perinatal mortality. One model included the level of BTM antibodies in a specified period before or after the outcome had occurred. The other model included the change in antibodies over time. These predictors were included both at herd and animal level. Furthermore, all models included parity and breed. Results: The individual monthly BTM antibody levels were highly correlated within herds. Consequently, changes in BTM antibody levels were not found to be associated with neither risk of stillbirth nor the risk of perinatal mortality. However, the risk of stillborn calves and perinatal death was higher with high level of BTM antibodies 8 to 9 months after the incident, but not outside this period. Conclusion: We conclude that the level of antibodies to C. burnetii in BTM may be associated with perinatal mortality, but the association was not persistent and should be investigated further.

AB - Background: Coxiella burnetii is a well-known cause of placentitis and subsequent abortion in ruminants, but there are no reports on the relationship with perinatal mortality. The study was performed to determine the influence of level and change of bulk tank milk (BTM) antibodies to C. burnetii on two outcomes associated with parturition in cattle: a) stillbirth; and b) stillbirth and neonatal mortality combined (perinatal death). Methods: Twenty-four Danish dairy herds were tested repeatedly for antibodies to C. burnetii in BTM using a commercial ELISA. Samples were collected monthly from July 2008 to July 2009. Information on the 2,362 calvings occurring in the study period was obtained from the Danish Cattle Database. Two multilevel logistic regression models were created for the two outcomes stillbirth and perinatal mortality. One model included the level of BTM antibodies in a specified period before or after the outcome had occurred. The other model included the change in antibodies over time. These predictors were included both at herd and animal level. Furthermore, all models included parity and breed. Results: The individual monthly BTM antibody levels were highly correlated within herds. Consequently, changes in BTM antibody levels were not found to be associated with neither risk of stillbirth nor the risk of perinatal mortality. However, the risk of stillborn calves and perinatal death was higher with high level of BTM antibodies 8 to 9 months after the incident, but not outside this period. Conclusion: We conclude that the level of antibodies to C. burnetii in BTM may be associated with perinatal mortality, but the association was not persistent and should be investigated further.

KW - Coxiella burnetii

KW - Cattle

KW - Perinatal death

KW - Stillbirth

U2 - 10.1186/1751-0147-53-64

DO - 10.1186/1751-0147-53-64

JO - Acta Veterinaria Scandinavica (Print)

JF - Acta Veterinaria Scandinavica (Print)

SN - 0044-605X

VL - 53

SP - 64

ER -