Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

Research output: Research - peer-reviewJournal article – Annual report year: 2015

  • Author: Simon, Levente L.

    BASF Schweiz AG, Switzerland

  • Author: Pataki, Hajnalka

    Budapest University of Technology and Economics, Hungary

  • Author: Marosi, György

    Budapest University of Technology and Economics, Hungary

  • Author: Meemken, Fabian

    Swiss Federal Institute of Technology Zurich, Switzerland

  • Author: Hungerbühler, Konrad

    Swiss Federal Institute of Technology Zurich, Switzerland

  • Author: Baiker, Alfons

    Swiss Federal Institute of Technology Zurich, Switzerland

  • Author: Tummala, Srinivas

    Bristol-Myers Squibb Company, United States

  • Author: Glennon, Brian

    University College Dublin, Ireland

  • Author: Kuentz, Martin

    University of Applied Sciences and Arts Northwestern Switzerland, Switzerland

  • Author: Steele, Gerry

    PharmaCryst Consulting Ltd., United Kingdom

  • Author: Kramer, Herman J. M.

    Delft University of Technology, Netherlands

  • Author: Rydzak, James W.

    GlaxoSmithKline Pharmaceuticals Ltd., United States

  • Author: Chen, Zengping

    Hunan University, China

  • Author: Morris, Julian

    Newcastle University, United Kingdom

  • Author: Kjell, Francois

    Siemens N.V./S.A., Belgium

  • Author: Singh, Ravendra

    CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark

  • Author: Gani, Rafiqul

    CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Gernaey, Krist V.

    CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Louhi-Kultanen, Marjatta

    Lappeenranta University of Technology, Finland

  • Author: Oreilly, John

    Roche Ireland Limited, Ireland

  • Author: Sandler, Niklas

    Åbo Akademi University, Finland

  • Author: Antikainen, Osmo

    University of Helsinki, Finland

  • Author: Yliruusi, Jouko

    University of Helsinki, Finland

  • Author: Frohberg, Patrick

    Martin Luther University Halle-Wittenberg, Germany

  • Author: Ulrich, Joachim

    Martin Luther University Halle-Wittenberg, Germany

  • Author: Braatz, Richard D.

    Massachusetts Institute of Technology, United States

  • Author: Leyssens, Tom

    Universite Catholique de Louvain, Belgium

  • Author: Von Stosch, Moritz

    NOVA University Lisbon, Portugal

  • Author: Oliveira, Rui

    NOVA University Lisbon, Portugal

  • Author: Tan, Reginald B. H.

    National University of Singapore, Singapore

  • Author: Wu, Huiquan

    United States Food and Drug Administration, United States

  • Author: Khan, Mansoor

    United States Food and Drug Administration, United States

  • Author: Ogrady, Des

    Mettler-Toledo LLC, United States

  • Author: Pandey, Anjan

    Mettler-Toledo LLC, United States

  • Author: Westra, Remko

    FMC Technologies B.V., Netherlands

  • Author: Delle-Case, Emmanuel

    University of Tulsa, United States

  • Author: Pape, Detlef

    ABB Group, Switzerland

  • Author: Angelosante, Daniele

    ABB Group, Switzerland

  • Author: Maret, Yannick

    ABB Group, Switzerland

  • Author: Steiger, Olivier

    ABB Group, Switzerland

  • Author: Lenner, Miklós

    ABB Group, Switzerland

  • Author: Abbou-Oucherif, Kaoutar

    Purdue University, United States

  • Author: Nagy, Zoltan K.

    Purdue University, United States

  • Author: Litster, James D.

    Purdue University, United States

  • Author: Kamaraju, Vamsi Krishna

    University College Dublin, Ireland

  • Author: Chiu, Min-Sen

    National University of Singapore, Singapore

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This multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept of a multiauthor review was born. Each section of the multiauthor review has been written by a single expert or group of experts with the aim to report on its own research results. This paper also serves as a comprehensive source of information on PAT topics for the novice reader.
Original languageEnglish
JournalOrganic Process Research and Development
Volume19
Issue number1
Pages (from-to)3-62
ISSN1083-6160
DOIs
StatePublished - 2015
CitationsWeb of Science® Times Cited: 102

    Research areas

  • Patient monitoring, Process monitoring, Astra zeneca, Process analytical technology, Process monitoring and control, Research results, Sensor development, Chemical sensors
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