Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Standard

Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions. / Verhagen, Hans; Andersen, Rikke; Antoine, Jean-Michel; Finglas, Paul; Hoekstra, Jeljer; Kardinaal, Alwine; Nordmann, Hervé; Pekcan, Gülden; Pentieva, Kristina; Sandersi, Tom A.; Berg, Henk van den; Kranen, Henk van; Chiodini, Alessandro.

In: Food and Chemical Toxicology, Vol. 50, No. Suppl. 4, 2011, p. s710-s723.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Harvard

Verhagen, H, Andersen, R, Antoine, J-M, Finglas, P, Hoekstra, J, Kardinaal, A, Nordmann, H, Pekcan, G, Pentieva, K, Sandersi, TA, Berg, HVD, Kranen, HV & Chiodini, A 2011, 'Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions' Food and Chemical Toxicology, vol 50, no. Suppl. 4, pp. s710-s723., 10.1016/j.fct.2011.06.068

APA

Verhagen, H., Andersen, R., Antoine, J-M., Finglas, P., Hoekstra, J., Kardinaal, A., ... Chiodini, A. (2011). Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions. Food and Chemical Toxicology, 50(Suppl. 4), s710-s723. 10.1016/j.fct.2011.06.068

CBE

Verhagen H, Andersen R, Antoine J-M, Finglas P, Hoekstra J, Kardinaal A, Nordmann H, Pekcan G, Pentieva K, Sandersi TA, Berg HVD, Kranen HV, Chiodini A. 2011. Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions. Food and Chemical Toxicology. 50(Suppl. 4):s710-s723. Available from: 10.1016/j.fct.2011.06.068

MLA

Vancouver

Author

Verhagen, Hans; Andersen, Rikke; Antoine, Jean-Michel; Finglas, Paul; Hoekstra, Jeljer; Kardinaal, Alwine; Nordmann, Hervé; Pekcan, Gülden; Pentieva, Kristina; Sandersi, Tom A.; Berg, Henk van den; Kranen, Henk van; Chiodini, Alessandro / Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions.

In: Food and Chemical Toxicology, Vol. 50, No. Suppl. 4, 2011, p. s710-s723.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{da9095820c354013a7b182f62862babe,
title = "Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions",
publisher = "Pergamon",
author = "Hans Verhagen and Rikke Andersen and Jean-Michel Antoine and Paul Finglas and Jeljer Hoekstra and Alwine Kardinaal and Hervé Nordmann and Gülden Pekcan and Kristina Pentieva and Sandersi, {Tom A.} and Berg, {Henk van den} and Kranen, {Henk van} and Alessandro Chiodini",
year = "2011",
doi = "10.1016/j.fct.2011.06.068",
volume = "50",
number = "Suppl. 4",
pages = "s710--s723",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",

}

RIS

TY - JOUR

T1 - Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions

A1 - Verhagen,Hans

A1 - Andersen,Rikke

A1 - Antoine,Jean-Michel

A1 - Finglas,Paul

A1 - Hoekstra,Jeljer

A1 - Kardinaal,Alwine

A1 - Nordmann,Hervé

A1 - Pekcan,Gülden

A1 - Pentieva,Kristina

A1 - Sandersi,Tom A.

A1 - Berg,Henk van den

A1 - Kranen,Henk van

A1 - Chiodini,Alessandro

AU - Verhagen,Hans

AU - Andersen,Rikke

AU - Antoine,Jean-Michel

AU - Finglas,Paul

AU - Hoekstra,Jeljer

AU - Kardinaal,Alwine

AU - Nordmann,Hervé

AU - Pekcan,Gülden

AU - Pentieva,Kristina

AU - Sandersi,Tom A.

AU - Berg,Henk van den

AU - Kranen,Henk van

AU - Chiodini,Alessandro

PB - Pergamon

PY - 2011

Y1 - 2011

N2 - The respective examples, described in this paper, illustrate how the BRAFO-tiered approach, on benefit–risk assessment, can be tested on a wide range of case studies. Various results were provided, ranging from a quick stop as the result of non-genuine benefit–risk questions to continuation through the tiers into deterministic/probabilistic calculations. The paper illustrates the assessment of benefits and risks associated with dietary interventions. The BRAFO tiered approach is tested with five case studies. In each instance, the benefit–risk approach is tested on the basis of existing evaluations for the individual effects done by others; no new risk or benefit evaluations were made. The following case studies were thoroughly analysed: an example of food fortification, folic acid fortification of flour, macronutrient replacement/food substitution; the isocaloric replacement of saturated fatty acids with carbohydrates; the replacement of saturated fatty acids with monounsaturated fatty acids; the replacement of sugar-sweetened beverages containing mono- and disaccharides with low calorie sweeteners and an example of addition of specific ingredients to food: chlorination of drinking water.

AB - The respective examples, described in this paper, illustrate how the BRAFO-tiered approach, on benefit–risk assessment, can be tested on a wide range of case studies. Various results were provided, ranging from a quick stop as the result of non-genuine benefit–risk questions to continuation through the tiers into deterministic/probabilistic calculations. The paper illustrates the assessment of benefits and risks associated with dietary interventions. The BRAFO tiered approach is tested with five case studies. In each instance, the benefit–risk approach is tested on the basis of existing evaluations for the individual effects done by others; no new risk or benefit evaluations were made. The following case studies were thoroughly analysed: an example of food fortification, folic acid fortification of flour, macronutrient replacement/food substitution; the isocaloric replacement of saturated fatty acids with carbohydrates; the replacement of saturated fatty acids with monounsaturated fatty acids; the replacement of sugar-sweetened beverages containing mono- and disaccharides with low calorie sweeteners and an example of addition of specific ingredients to food: chlorination of drinking water.

U2 - 10.1016/j.fct.2011.06.068

DO - 10.1016/j.fct.2011.06.068

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - Suppl. 4

VL - 50

SP - s710-s723

ER -