Apolipoprotein E deficiency increases remnant lipoproteins and accelerates progressive atherosclerosis in Yucatan minipigs

Research output: Contribution to journalConference abstract in journal – Annual report year: 2018Researchpeer-review

  • Author: Shim, J.

    Aarhus University, Denmark

  • Author: Poulsen, C. B.

    Aarhus University, Denmark

  • Author: Hagensen, Morten

    Aarhus University, Denmark

  • Author: Larsen, T

    Aarhus University, Denmark

  • Author: Heegaard, P. M. H.

    Innate Immunology, Division of Immunology & Vaccinology, National Veterinary Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Christoffersen, Carsten

    Righospitalet , Denmark

  • Author: Bolund, L.

    Aarhus University, Denmark

  • Author: Schmidt, M.

    University of Copenhagen, Denmark

  • Author: Liu, Y

    Aarhus University, Denmark

  • Author: Li, J.

    Aarhus University, Denmark

  • Author: Li, R.

    Aarhus University, Denmark

  • Author: Callesen, H.

    Aarhus University, Denmark

  • Author: Bentzon, J. F.

    Aarhus University, Denmark

  • Author: Sørensen, C. B.

    Aarhus University, Denmark

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Apolipoprotein E (APOE) mediates hepatic uptake of lipoproteins through the low-density lipoprotein receptor and low-density receptor-related protein 1. Defects or deficiency of APOE causes familial dysbetalipoproteinemia in humans characterized by accumulations of VLDL, IDL, and chylomicron remnants as well as a higher risk of atherosclerotic disease. APOE is also involved in controlling smooth muscle cell proliferation and migration, reverse cholesterol transport and inflammation.
Original languageEnglish
JournalTransgenic Research
Volume27
Issue number5
Pages (from-to)484-484
ISSN0962-8819
DOIs
Publication statusPublished - 2018
EventUC Davis Transgenic Animal Research Conference XI - e Granlibakken Conference Center and Resort, Tahoe, United States
Duration: 13 Aug 201717 Aug 2017
Conference number: 11

Conference

ConferenceUC Davis Transgenic Animal Research Conference XI
Number11
Locatione Granlibakken Conference Center and Resort
CountryUnited States
CityTahoe
Period13/08/201717/08/2017
CitationsWeb of Science® Times Cited: No match on DOI
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