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  • Author: Conde, Virginia

    University of Copenhagen, Denmark

  • Author: Andreasen, Sara Hesby

    University of Copenhagen, Denmark

  • Author: Petersen, Tue Hvass

    University of Copenhagen, Denmark

  • Author: Larsen, Karen Busted

    University of Copenhagen, Denmark

  • Author: Madsen, Karine

    University of Copenhagen, Denmark

  • Author: Andersen, Kasper Winther

    University of Copenhagen, Denmark

  • Author: Akopian, Irina

    University of Copenhagen, Denmark

  • Author: Madsen, Kristoffer Hougaard

    Cognitive Systems, Department of Applied Mathematics and Computer Science , Technical University of Denmark, Denmark

  • Author: Hansen, Christian Pilebæk

    University of Copenhagen, Denmark

  • Author: Poulsen, Ingrid

    University of Copenhagen, Denmark

  • Author: Kammersgaard, Lars Peter

    University of Copenhagen, Denmark

  • Author: Siebner, Hartwig Roman

    University of Copenhagen, Denmark

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Introduction Traumatic brain injury (TBI) is considered one of the most pervasive causes of disability in people under the age of 45. TBI often results in disorders of consciousness, and clinical assessment of the state of consciousness in these patients is challenging due to the lack of behavioural responsiveness. Functional neuroimaging offers a means to assess these patients without the need for behavioural signs, indicating that brain connectivity plays a major role in consciousness emergence and maintenance. However, little is known regarding how changes in connectivity during recovery from TBI accompany changes in the level of consciousness. Here, we aim to combine cutting-edge neuroimaging techniques to follow changes in brain connectivity in patients recovering from severe TBI. Methods and analysis A multimodal, longitudinal assessment of 30 patients in the subacute stage after severe TBI will be made comprising an MRI session combined with electroencephalography (EEG), a positron emission tomography session and a transcranial magnetic stimulation (TMS) combined with EEG (TMS/EEG) session. A group of 20 healthy participants will be included for comparison. Four sessions for patients and two sessions for healthy participants will be planned. Data analysis techniques will focus on whole-brain, both data-driven and hypothesis-driven, connectivity measures that will be specific to the imaging modality. Ethics and dissemination The project has received ethical approval by the local ethics committee of the Capital Region of Denmark and by the Danish Data Protection. Results will be published as original research articles in peer-reviewed journals and disseminated in international conferences. None of the measurements will have any direct clinical impact on the patients included in the study but may benefit future patients through a better understanding of the mechanisms underlying the recovery process after TBI. Trial registration number: NCT02424656; Pre-results.
Original languageEnglish
JournalOpen Journal of Ecology
Volume7
Issue number6
Number of pages10
ISSN2162-1985
DOIs
StatePublished - 2017
CitationsWeb of Science® Times Cited: 0

    Keywords

  • Journal Article, Medicine (all), Brain connectivity, Disorders of Consciousness, Longitudinal study, Multimodal study, Neuroimaging, Traumatic Brain Injury
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