All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

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All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication. / Tanzi, S.; Larsen, S.T.; Matteucci, M.; Taboryski, R.

Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo. 2012. p. 376-379.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Harvard

APA

CBE

Tanzi S, Larsen ST, Matteucci M, Taboryski R. 2012. All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication. In Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo. pp. 376-379.

MLA

Tanzi, S. et al. "All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication". Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo. 2012. 376-379.

Vancouver

Author

Tanzi, S.; Larsen, S.T.; Matteucci, M.; Taboryski, R. / All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication.

Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo. 2012. p. 376-379.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Bibtex

@inbook{78f03df7bf12405fbfdd21fe5a59ff24,
title = "All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication",
author = "S. Tanzi and S.T. Larsen and M. Matteucci and R. Taboryski",
year = "2012",
pages = "376-379",
booktitle = "Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo",

}

RIS

TY - ABST

T1 - All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication

A1 - Tanzi,S.

A1 - Larsen,S.T.

A1 - Matteucci,M.

A1 - Taboryski,R.

AU - Tanzi,S.

AU - Larsen,S.T.

AU - Matteucci,M.

AU - Taboryski,R.

PY - 2012

Y1 - 2012

N2 - This work demonstrates a novel all-in-polymer device for single cell capture applicable for biological recordings. The chip is injection molded and comprises a "cornered" (non planar) aperture. It has been demonstrated how cornered apertures are straightforward to mold in PDMS [1,2]. In this study we demonstrate cornered apertures made in a thermoplastic polymer. One of the advantages of cornered apertures is the ease of microscopy under a standard inverted optical microscope, when using transparent materials. After the part is injection molded, the sealing of the chip is performed by thermal bonding to a polymer foil, so the complete device results from only two parts. It differs from similar devices in the novel material and fabrication platform that enables high reproducibility and inexpensive mass production. Optimization of the fabrication scheme has been carried out in order to avoid defects during demolding. Capturing of single PC12 cells has been demonstrated.

AB - This work demonstrates a novel all-in-polymer device for single cell capture applicable for biological recordings. The chip is injection molded and comprises a "cornered" (non planar) aperture. It has been demonstrated how cornered apertures are straightforward to mold in PDMS [1,2]. In this study we demonstrate cornered apertures made in a thermoplastic polymer. One of the advantages of cornered apertures is the ease of microscopy under a standard inverted optical microscope, when using transparent materials. After the part is injection molded, the sealing of the chip is performed by thermal bonding to a polymer foil, so the complete device results from only two parts. It differs from similar devices in the novel material and fabrication platform that enables high reproducibility and inexpensive mass production. Optimization of the fabrication scheme has been carried out in order to avoid defects during demolding. Capturing of single PC12 cells has been demonstrated.

KW - Dry etching

KW - Exhibitions

KW - Fabrication

KW - Fluidics

KW - Injection molding

KW - Polymers

KW - Nanotechnology

BT - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo

T2 - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo

SP - 376

EP - 379

ER -