All polymer chip for amperometric studies of transmitter release from large groups of neuronal cells

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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We present an all polymer electrochemical chip for simple detection of transmitter release from large groups of cultured PC 12 cells. Conductive polymer PEDOT:tosylate microelectrodes were used together with constant potential amperometry to obtain easy-to-analyze oxidation signals from potassium-induced release of transmitter molecules. The nature of the resulting current peaks is discussed, and the time for restoring transmitter reservoirs is studied. The relationship between released transmitters and potassium concentration was found to fit to a sigmoidal dose–response curve. Finally, we demonstrate how the presented device can be used for simple drug screening purposes, by measuring the increase of transmitter release due to short-term treatment with l-DOPA.
Original languageEnglish
JournalAnalyst
Publication date2012
Volume137
Journal number21
Pages5057-5061
ISSN0003-2654
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 4
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