Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Standard

Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. / Tolstrup, J.S.; Hansen, J.L.; Gronbaek, M.; Vogel, Ulla Birgitte; Tjonneland, A.; Joensen, A.M.; Overvad, K.

In: Scandinavian Journal of Public Health, Vol. 38, No. 5, 2010, p. 489-494.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Harvard

Tolstrup, JS, Hansen, JL, Gronbaek, M, Vogel, UB, Tjonneland, A, Joensen, AM & Overvad, K 2010, 'Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome' Scandinavian Journal of Public Health, vol 38, no. 5, pp. 489-494., 10.1177/1403494810371248

APA

Tolstrup, J. S., Hansen, J. L., Gronbaek, M., Vogel, U. B., Tjonneland, A., Joensen, A. M., & Overvad, K. (2010). Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. Scandinavian Journal of Public Health, 38(5), 489-494. 10.1177/1403494810371248

CBE

Tolstrup JS, Hansen JL, Gronbaek M, Vogel UB, Tjonneland A, Joensen AM, Overvad K. 2010. Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. Scandinavian Journal of Public Health. 38(5):489-494. Available from: 10.1177/1403494810371248

MLA

Vancouver

Author

Tolstrup, J.S.; Hansen, J.L.; Gronbaek, M.; Vogel, Ulla Birgitte; Tjonneland, A.; Joensen, A.M.; Overvad, K. / Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome.

In: Scandinavian Journal of Public Health, Vol. 38, No. 5, 2010, p. 489-494.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Bibtex

@article{5d57e61474ff47328dd5cbae5371168e,
title = "Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome",
publisher = "Sage Science Press (UK)",
author = "J.S. Tolstrup and J.L. Hansen and M. Gronbaek and Vogel, {Ulla Birgitte} and A. Tjonneland and A.M. Joensen and K. Overvad",
year = "2010",
doi = "10.1177/1403494810371248",
volume = "38",
number = "5",
pages = "489--494",
journal = "Scandinavian Journal of Public Health",
issn = "1403-4948",

}

RIS

TY - JOUR

T1 - Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

A1 - Tolstrup,J.S.

A1 - Hansen,J.L.

A1 - Gronbaek,M.

A1 - Vogel,Ulla Birgitte

A1 - Tjonneland,A.

A1 - Joensen,A.M.

A1 - Overvad,K.

AU - Tolstrup,J.S.

AU - Hansen,J.L.

AU - Gronbaek,M.

AU - Vogel,Ulla Birgitte

AU - Tjonneland,A.

AU - Joensen,A.M.

AU - Overvad,K.

PB - Sage Science Press (UK)

PY - 2010

Y1 - 2010

N2 - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

AB - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

KW - alcohol

KW - Acute coronary syndrome

KW - genetic epidemiology

KW - cohort study

U2 - 10.1177/1403494810371248

DO - 10.1177/1403494810371248

JO - Scandinavian Journal of Public Health

JF - Scandinavian Journal of Public Health

SN - 1403-4948

IS - 5

VL - 38

SP - 489

EP - 494

ER -