Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data

Publication: Research - peer-reviewJournal article – Annual report year: 2013

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This paper presents an integrated model of convective O2-transport, aerobic dive limits (ADL), and thermochemical
data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations
in Mb on the dive limits of Weddell seals (Leptonychotes weddellii). We find that wild-type Mb traits are
only superior under specific behavioral and physiological conditions that critically prolong the ADL, action radius,
and fitness of the seals. As an extreme example, the mutations in the conserved His-64 reduce ADL up to
14±2 min for routine aerobic dives, whereas many other mutations are nearly neutral in terms of ADL and
the inferred fitness. We also find that the cardiac system, the muscle O2-store, animal behavior (i.e. pre-dive
ventilation), and the oxygen binding affinity of Mb, KO2, have co-evolved to optimize dive duration at routine
aerobic diving conditions, suggesting that such conditions are mostly selected upon in seals. The model is capable
of roughly quantifying the physiological impact of single-protein mutations and thus bridges an important
gap between animal physiology and molecular (protein) evolution.

Original languageEnglish
JournalComparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology
Publication date2013
Volume164
Pages119-128
ISSN1095-6433
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 2

Keywords

  • Myoglobin, Aerobic dive limit, Protein mutations, Fitness, Seals
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