Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

Publication: Research - peer-reviewConference article – Annual report year: 2012

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@article{3519b76a7270454a8ff9b7f8bc3ba721,
title = "Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides",
keywords = "Epoxiconazole, Mancozeb, Prochloraz, Tebuconazole, Procymidone, Rat, Mixture, Developmental, Endocrine disrupter, Nipple retention",
publisher = "Elsevier Inc.",
author = "Ulla Hass and Julie Boberg and Sofie Christiansen and Jacobsen, {Pernille Rosenskjold} and Vinggaard, {Anne Marie} and Camilla Taxvig and Poulsen, {Mette Erecius} and Herrmann, {Susan Strange} and Jensen, {Bodil Hamborg} and Annette Petersen and Clemmensen, {Line Katrine Harder} and Petersen, {Marta Axelstad}",
year = "2012",
doi = "10.1016/j.reprotox.2012.05.090",
volume = "34",
number = "2",
pages = "261--274",
journal = "Reproductive Toxicology",
issn = "0890-6238",

}

RIS

TY - CONF

T1 - Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

A1 - Hass,Ulla

A1 - Boberg,Julie

A1 - Christiansen,Sofie

A1 - Jacobsen,Pernille Rosenskjold

A1 - Vinggaard,Anne Marie

A1 - Taxvig,Camilla

A1 - Poulsen,Mette Erecius

A1 - Herrmann,Susan Strange

A1 - Jensen,Bodil Hamborg

A1 - Petersen,Annette

A1 - Clemmensen,Line Katrine Harder

A1 - Petersen,Marta Axelstad

AU - Hass,Ulla

AU - Boberg,Julie

AU - Christiansen,Sofie

AU - Jacobsen,Pernille Rosenskjold

AU - Vinggaard,Anne Marie

AU - Taxvig,Camilla

AU - Poulsen,Mette Erecius

AU - Herrmann,Susan Strange

AU - Jensen,Bodil Hamborg

AU - Petersen,Annette

AU - Clemmensen,Line Katrine Harder

AU - Petersen,Marta Axelstad

PB - Elsevier Inc.

PY - 2012

Y1 - 2012

N2 - The present study investigated whether a mixture of low doses of five environmentally relevant endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, would cause adverse developmental toxicity effects in rats. In rat dams, a significant increase in gestation length was seen, while in male offspring increased nipple retention and increased incidence and severity of genital malformations were observed. Severe mixture effects on gestation length, nipple retention and genital malformations were seen at dose levels where the individual pesticides caused no or smaller effects when given alone. Generally, the mixture effect predictions based on dose-additivity were in good agreement with the observed effects. The results indicate that there is a need for modification of risk assessment procedures for pesticides, in order to take account of the mixture effects and cumulative intake, because of the potentially serious impact of mixed exposure on development and reproduction in humans.

AB - The present study investigated whether a mixture of low doses of five environmentally relevant endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, would cause adverse developmental toxicity effects in rats. In rat dams, a significant increase in gestation length was seen, while in male offspring increased nipple retention and increased incidence and severity of genital malformations were observed. Severe mixture effects on gestation length, nipple retention and genital malformations were seen at dose levels where the individual pesticides caused no or smaller effects when given alone. Generally, the mixture effect predictions based on dose-additivity were in good agreement with the observed effects. The results indicate that there is a need for modification of risk assessment procedures for pesticides, in order to take account of the mixture effects and cumulative intake, because of the potentially serious impact of mixed exposure on development and reproduction in humans.

KW - Epoxiconazole

KW - Mancozeb

KW - Prochloraz

KW - Tebuconazole

KW - Procymidone

KW - Rat

KW - Mixture

KW - Developmental

KW - Endocrine disrupter

KW - Nipple retention

U2 - 10.1016/j.reprotox.2012.05.090

DO - 10.1016/j.reprotox.2012.05.090

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - 2

VL - 34

SP - 261

EP - 274

ER -