By viewing the construction industry as a technological innovation system (TIS) this paper discusses possible initiatives to accelerate nanotechnological innovations. The point of departure is a recent report on the application of nano-technology in the Danish construction industry, which concludes that opportunities are generally poorly appreciated by the industry and research communities alike. It is found that the construction industry is characterized by low-tech trajectories where dedicated innovation networks are often too fragile for innovations to stabilize and diffuse. The institutional features of the system are furthermore poorly equipped at identifying potentials within high-tech areas. In order to exploit the potentials of nano-technology it is thus argued that an alternative TIS needs to be established. Initiatives should identify and support “incubation rooms” or marked niches in order for the different elements of the TIS to evolve. This could involve nano-visioning including scenarios of future technological applications and industrial dynamics.