TY - JOUR

T1 - A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes

A1 - Lutze,Philip

A1 - Roman Martinez,Alicia

A1 - Woodley,John

A1 - Gani,Rafiqul

AU - Lutze,Philip

AU - Roman Martinez,Alicia

AU - Woodley,John

AU - Gani,Rafiqul

PB - Pergamon

PY - 2012/1/10

Y1 - 2012/1/10

N2 - Process intensification (PI) has the potential to improve existing processes or create new process options, which are needed in order to produce products using more sustainable methods. In principle, an enormous number of process options can be generated but where and how the process should be intensified for the biggest improvement is difficult to identify. In this paper the development of a systematic computer aided model-based synthesis and design methodology incorporating PI is presented. In order to manage the complexities involved, the methodology employs a decomposition-based solution approach. Starting from an analysis of existing processes, the methodology generates a set of process options and reduces their number through several screening steps until from the remaining options, the optimal is found. The application of the methodology is highlighted through a case study involving the chemo-enzymatic synthesis of N-acetyl-d-neuraminic acid (Neu5Ac).

AB - Process intensification (PI) has the potential to improve existing processes or create new process options, which are needed in order to produce products using more sustainable methods. In principle, an enormous number of process options can be generated but where and how the process should be intensified for the biggest improvement is difficult to identify. In this paper the development of a systematic computer aided model-based synthesis and design methodology incorporating PI is presented. In order to manage the complexities involved, the methodology employs a decomposition-based solution approach. Starting from an analysis of existing processes, the methodology generates a set of process options and reduces their number through several screening steps until from the remaining options, the optimal is found. The application of the methodology is highlighted through a case study involving the chemo-enzymatic synthesis of N-acetyl-d-neuraminic acid (Neu5Ac).

KW - Process intensification

KW - Process synthesis

KW - Knowledge base

KW - Methodology

U2 - 10.1016/j.compchemeng.2011.08.005

DO - 10.1016/j.compchemeng.2011.08.005

JO - Computers & Chemical Engineering

JF - Computers & Chemical Engineering

SN - 0098-1354

VL - 36

SP - 189

EP - 207

ER -