A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

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A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation. / Christiansen, Thomas Lehrmann; Trosborg, Jacqueline; Tanzi, Simone; Larsen, Simon Tylsgaard; Taboryski, Rafael J.

Proceedings of NSTI-Nanotech 2012. Vol. 2 2012. p. 470-473.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

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Christiansen, Thomas Lehrmann; Trosborg, Jacqueline; Tanzi, Simone; Larsen, Simon Tylsgaard; Taboryski, Rafael J. / A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation.

Proceedings of NSTI-Nanotech 2012. Vol. 2 2012. p. 470-473.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

Bibtex

@inbook{588e066f06ec4e8fa30144afcb7ae1b5,
title = "A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation",
keywords = "Pinched flow fractionation, Pressure control, Modified liga process, Injection molding, Cleanroom processing, Microfluidics, Point-of-care",
author = "Christiansen, {Thomas Lehrmann} and Jacqueline Trosborg and Simone Tanzi and Larsen, {Simon Tylsgaard} and Taboryski, {Rafael J.}",
year = "2012",
volume = "2",
pages = "470-473",
booktitle = "Proceedings of NSTI-Nanotech 2012",

}

RIS

TY - ABST

T1 - A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation

A1 - Christiansen,Thomas Lehrmann

A1 - Trosborg,Jacqueline

A1 - Tanzi,Simone

A1 - Larsen,Simon Tylsgaard

A1 - Taboryski,Rafael J.

AU - Christiansen,Thomas Lehrmann

AU - Trosborg,Jacqueline

AU - Tanzi,Simone

AU - Larsen,Simon Tylsgaard

AU - Taboryski,Rafael J.

PY - 2012

Y1 - 2012

N2 - In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.

AB - In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.

KW - Pinched flow fractionation

KW - Pressure control

KW - Modified liga process

KW - Injection molding

KW - Cleanroom processing

KW - Microfluidics

KW - Point-of-care

VL - 2

BT - Proceedings of NSTI-Nanotech 2012

T2 - Proceedings of NSTI-Nanotech 2012

SP - 470

EP - 473

ER -