A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation
Publication: Research - peer-review › Conference abstract in proceedings – Annual report year: 2012
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A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation. / Christiansen, Thomas Lehrmann; Trosborg, Jacqueline; Tanzi, Simone; Larsen, Simon Tylsgaard; Taboryski, Rafael J.
In: Proceedings of NSTI-Nanotech 2012. Vol. 2 2012. p. 470-473.Publication: Research - peer-review › Conference abstract in proceedings – Annual report year: 2012
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TY - ABST
T1 - A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation
A1 - Christiansen,Thomas Lehrmann
A1 - Trosborg,Jacqueline
A1 - Tanzi,Simone
A1 - Larsen,Simon Tylsgaard
A1 - Taboryski,Rafael J.
AU - Christiansen,Thomas Lehrmann
AU - Trosborg,Jacqueline
AU - Tanzi,Simone
AU - Larsen,Simon Tylsgaard
AU - Taboryski,Rafael J.
PY - 2012
Y1 - 2012
N2 - In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.
AB - In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.
KW - Pinched flow fractionation
KW - Pressure control
KW - Modified liga process
KW - Injection molding
KW - Cleanroom processing
KW - Microfluidics
KW - Point-of-care
VL - 2
BT - Proceedings of NSTI-Nanotech 2012
T2 - Proceedings of NSTI-Nanotech 2012
SP - 470
EP - 473
ER -