A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2012

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In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.
Original languageEnglish
Title of host publicationProceedings of NSTI-Nanotech 2012
Volume2
Publication date2012
Pages470-473
ISBN (electronic)978-1-4665-6275-2
StatePublished

Conference

ConferenceNanotech 2012
Number15
CountryUnited States
CitySanta Clara
Period18/06/1221/06/12

Keywords

  • Pinched flow fractionation, Pressure control, Modified liga process, Injection molding, Cleanroom processing, Microfluidics, Point-of-care
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