A perspective on PSE in pharmaceutical process development and innovation

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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A perspective on PSE in pharmaceutical process development and innovation. / Gernaey, Krist; Cervera Padrell, Albert Emili; Woodley, John.

In: Computers & Chemical Engineering, Vol. 42, No. Special issue of ESCAPE-21, 2012, p. 15-29.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Gernaey, Krist; Cervera Padrell, Albert Emili; Woodley, John / A perspective on PSE in pharmaceutical process development and innovation.

In: Computers & Chemical Engineering, Vol. 42, No. Special issue of ESCAPE-21, 2012, p. 15-29.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{188f2dfe6e5e4e56b1419bb395b68661,
title = "A perspective on PSE in pharmaceutical process development and innovation",
keywords = "Continuous pharmaceutical manufacturing, Design space, PAT, Pharmaceutical production, Process development, Sustainability",
publisher = "Pergamon",
author = "Krist Gernaey and {Cervera Padrell}, {Albert Emili} and John Woodley",
note = "Based on paper presented at the 21st European Symposium on Computer-Aided Process Engineering (ESCAPE-21), Greece 2011.",
year = "2012",
doi = "10.1016/j.compchemeng.2012.02.022",
volume = "42",
number = "Special issue of ESCAPE-21",
pages = "15--29",
journal = "Computers & Chemical Engineering",
issn = "0098-1354",

}

RIS

TY - JOUR

T1 - A perspective on PSE in pharmaceutical process development and innovation

A1 - Gernaey,Krist

A1 - Cervera Padrell,Albert Emili

A1 - Woodley,John

AU - Gernaey,Krist

AU - Cervera Padrell,Albert Emili

AU - Woodley,John

PB - Pergamon

PY - 2012

Y1 - 2012

N2 - The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.

AB - The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.

KW - Continuous pharmaceutical manufacturing

KW - Design space

KW - PAT

KW - Pharmaceutical production

KW - Process development

KW - Sustainability

U2 - 10.1016/j.compchemeng.2012.02.022

DO - 10.1016/j.compchemeng.2012.02.022

JO - Computers & Chemical Engineering

JF - Computers & Chemical Engineering

SN - 0098-1354

IS - Special issue of ESCAPE-21

VL - 42

SP - 15

EP - 29

ER -