A perspective on PSE in pharmaceutical process development and innovation

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.
Original languageEnglish
JournalComputers & Chemical Engineering
Publication date2012
Volume42
Journal numberSpecial issue of ESCAPE-21
Pages15-29
ISSN0098-1354
DOIs
StatePublished

Bibliographical note

Based on paper presented at the 21st European Symposium on Computer-Aided Process Engineering (ESCAPE-21), Greece 2011.

CitationsWeb of Science® Times Cited: 15

Keywords

  • Continuous pharmaceutical manufacturing, Design space, PAT, Pharmaceutical production, Process development, Sustainability
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