• Author: Erritzoe, David

    Copenhagen University Hospital

  • Author: Holst, Klaus

    Center for Integrated Molecular Brain Imaging

  • Author: Frokjaer, Vibe G.

    Copenhagen University Hospital

  • Author: Licht, Cecilie L.

    Copenhagen University Hospital

  • Author: Kalbitzer, Jan

    Copenhagen University Hospital

  • Author: Nielsen, Finn Årup

    Cognitive Systems, Department of Informatics and Mathematical Modeling, Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Svarer, Claus

    Copenhagen University Hospital

  • Author: Madsen, Jacob

    Copenhagen University Hospital

  • Author: Knudsen, Gitte Moos

    Copenhagen University Hospital

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Serotonergic neurotransmission is involved in the regulation of physiological functions such as mood, sleep, memory, and appetite. Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT2A) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Additionally, experimental studies suggest that alterations in either the 5-HT2A receptor or SERT level can affect the protein level of the counterpart. The aim of this study was to explore the covariation between cerebral 5-HT2A receptor and SERT in vivo in the same healthy human subjects. Fifty-six healthy human subjects with a mean age of 36 ± 19 years were investigated. The SERT binding was imaged with [11C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) and 5-HT2A receptor binding with [18F]altanserin using positron emission tomography. Within each individual, a regional intercorrelation for the various brain regions was seen with both markers, most notably for 5-HT2A receptor binding. An inverted U-shaped relationship between the 5-HT2A receptor and the SERT binding was identified. The observed regional intercorrelation for both the 5-HT2A receptor and the SERT cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. A quadratic relationship between the two markers is consistent with data from experimental studies of the effect on SERT and 5-HT2A receptor binding of chronic changes in 5-HT levels. That is, the observed association between the 5-HT2A receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand.
Original languageEnglish
JournalJournal of Neuroscience
Publication date2010
Volume30
Issue9
Pages3391-3397
ISSN0270-6474
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 19

Keywords

  • Neuroimaging
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