A human gut microbial gene catalogue established by metagenomic sequencing
Publication: Research - peer-review › Journal article – Annual report year: 2010
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here
we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant
microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set,
,150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent)
microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The
genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire
cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are
also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of
functions present in all individuals and most bacteria, respectively.
| Original language | English |
|---|---|
| Journal | Nature |
| Publication date | 2010 |
| Volume | 464 |
| Journal number | 7285 |
| Pages | 59 |
| ISSN | 0028-0836 |
| DOIs | |
| State | Published |
| Citations | Web of Science® Times Cited: 861 |
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ID: 4866934