TY - JOUR

T1 - A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.

A1 - Gregersen,Noomi

A1 - Dahl,Hans A.

A1 - Buttenschön,Henriette N.

A1 - Nyegaard,Mette

A1 - Hedemand,Anne

A1 - Als,Thomas Damm

A1 - Wang,August G.

A1 - Joensen,Sofus

A1 - Woldbye,David P.D.

A1 - Koefoed,Pernille

A1 - Kristensen,Ann S.

A1 - Kruse,Torben A.

A1 - Börglum,Anders D.

A1 - Mors,Ole

AU - Gregersen,Noomi

AU - Dahl,Hans A.

AU - Buttenschön,Henriette N.

AU - Nyegaard,Mette

AU - Hedemand,Anne

AU - Als,Thomas Damm

AU - Wang,August G.

AU - Joensen,Sofus

AU - Woldbye,David P.D.

AU - Koefoed,Pernille

AU - Kristensen,Ann S.

AU - Kruse,Torben A.

AU - Börglum,Anders D.

AU - Mors,Ole

PB - Nature Publishing Group

PY - 2012

Y1 - 2012

N2 - Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148.

AB - Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148.

U2 - 10.1038/ejhg.2011.148

DO - 10.1038/ejhg.2011.148

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 1

VL - 20

SP - 84

EP - 90

ER -