A generic process template for continuous pharmaceutical production
Publication: Research - peer-review › Article in proceedings – Annual report year: 2012
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A generic process template for continuous pharmaceutical production. / Singh, Ravendra; Rozada-Sanches, Raquel; Dean, William ; Perkins, Jacob; Muller, Frans; Godfrey, Andy; Gernaey, Krist; Gani, Rafiqul; Woodley, John.
In: Proceedings of the 11th International Symposium on Process Systems Engineering. ed. / I.A. Karimi; Rajagopalan Srinivasan. Elsevier BV, 2012. p. 715-719 (Computer Aided Chemical Engineering, Vol. 31).Publication: Research - peer-review › Article in proceedings – Annual report year: 2012
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TY - GEN
T1 - A generic process template for continuous pharmaceutical production
A1 - Singh,Ravendra
A1 - Rozada-Sanches,Raquel
A1 - Dean,William
A1 - Perkins,Jacob
A1 - Muller,Frans
A1 - Godfrey,Andy
A1 - Gernaey,Krist
A1 - Gani,Rafiqul
A1 - Woodley,John
AU - Singh,Ravendra
AU - Rozada-Sanches,Raquel
AU - Dean,William
AU - Perkins,Jacob
AU - Muller,Frans
AU - Godfrey,Andy
AU - Gernaey,Krist
AU - Gani,Rafiqul
AU - Woodley,John
PB - Elsevier BV
PY - 2012
Y1 - 2012
N2 - In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.
AB - In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.
KW - Process template
KW - API
KW - Substrate adoption
KW - Methodology
KW - Pharmaceutical
BT - Proceedings of the 11th International Symposium on Process Systems Engineering
T2 - Proceedings of the 11th International Symposium on Process Systems Engineering
A2 - Srinivasan,Rajagopalan
ED - Srinivasan,Rajagopalan
T3 - Computer Aided Chemical Engineering
T3 - en_GB
SP - 715
EP - 719
ER -