A generic process template for continuous pharmaceutical production

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Standard

A generic process template for continuous pharmaceutical production. / Singh, Ravendra; Rozada-Sanches, Raquel; Dean, William ; Perkins, Jacob; Muller, Frans; Godfrey, Andy; Gernaey, Krist; Gani, Rafiqul; Woodley, John.

Proceedings of the 11th International Symposium on Process Systems Engineering. ed. / I.A. Karimi; Rajagopalan Srinivasan. Elsevier Science, 2012. p. 715-719 (Computer Aided Chemical Engineering, Vol. 31).

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Harvard

Singh, R, Rozada-Sanches, R, Dean, W, Perkins, J, Muller, F, Godfrey, A, Gernaey, K, Gani, R & Woodley, J 2012, 'A generic process template for continuous pharmaceutical production'. in IA Karimi & R Srinivasan (eds), Proceedings of the 11th International Symposium on Process Systems Engineering. Elsevier Science, pp. 715-719. Computer Aided Chemical Engineering, vol. 31

APA

Singh, R., Rozada-Sanches, R., Dean, W., Perkins, J., Muller, F., Godfrey, A., Gernaey, K., Gani, R., & Woodley, J. (2012). A generic process template for continuous pharmaceutical production. In I. A. Karimi, & R. Srinivasan (Eds.), Proceedings of the 11th International Symposium on Process Systems Engineering. (pp. 715-719). Elsevier Science. (Computer Aided Chemical Engineering, Vol. 31).

CBE

Singh R, Rozada-Sanches R, Dean W, Perkins J, Muller F, Godfrey A, Gernaey K, Gani R, Woodley J. 2012. A generic process template for continuous pharmaceutical production. Karimi IA, Srinivasan R, editors. In Proceedings of the 11th International Symposium on Process Systems Engineering. Elsevier Science. pp. 715-719. (Computer Aided Chemical Engineering, Vol. 31).

MLA

Singh, Ravendra et al. "A generic process template for continuous pharmaceutical production". and Karimi, I.A. Srinivasan, Rajagopalan (ed.). Proceedings of the 11th International Symposium on Process Systems Engineering. Elsevier Science. 2012. 715-719. (Computer Aided Chemical Engineering, Volume 31).

Vancouver

Singh R, Rozada-Sanches R, Dean W, Perkins J, Muller F, Godfrey A et al. A generic process template for continuous pharmaceutical production. In Karimi IA, Srinivasan R, editors, Proceedings of the 11th International Symposium on Process Systems Engineering. Elsevier Science. 2012. p. 715-719. (Computer Aided Chemical Engineering, Vol. 31).

Author

Singh, Ravendra; Rozada-Sanches, Raquel; Dean, William ; Perkins, Jacob; Muller, Frans; Godfrey, Andy; Gernaey, Krist; Gani, Rafiqul; Woodley, John / A generic process template for continuous pharmaceutical production.

Proceedings of the 11th International Symposium on Process Systems Engineering. ed. / I.A. Karimi; Rajagopalan Srinivasan. Elsevier Science, 2012. p. 715-719 (Computer Aided Chemical Engineering, Vol. 31).

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Bibtex

@inbook{7e3408700f624515b354cc106ce927f7,
title = "A generic process template for continuous pharmaceutical production",
publisher = "Elsevier Science",
author = "Ravendra Singh and Raquel Rozada-Sanches and William Dean and Jacob Perkins and Frans Muller and Andy Godfrey and Krist Gernaey and Rafiqul Gani and John Woodley",
year = "2012",
editor = "I.A. Karimi and Rajagopalan Srinivasan",
series = "Computer Aided Chemical Engineering",
pages = "715-719",
booktitle = "Proceedings of the 11th International Symposium on Process Systems Engineering",

}

RIS

TY - GEN

T1 - A generic process template for continuous pharmaceutical production

A1 - Singh,Ravendra

A1 - Rozada-Sanches,Raquel

A1 - Dean,William

A1 - Perkins,Jacob

A1 - Muller,Frans

A1 - Godfrey,Andy

A1 - Gernaey,Krist

A1 - Gani,Rafiqul

A1 - Woodley,John

AU - Singh,Ravendra

AU - Rozada-Sanches,Raquel

AU - Dean,William

AU - Perkins,Jacob

AU - Muller,Frans

AU - Godfrey,Andy

AU - Gernaey,Krist

AU - Gani,Rafiqul

AU - Woodley,John

PB - Elsevier Science

PY - 2012

Y1 - 2012

N2 - In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.

AB - In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.

KW - Process template

KW - API

KW - Substrate adoption

KW - Methodology

KW - Pharmaceutical

BT - Proceedings of the 11th International Symposium on Process Systems Engineering

T2 - Proceedings of the 11th International Symposium on Process Systems Engineering

A2 - Srinivasan,Rajagopalan

ED - Srinivasan,Rajagopalan

T3 - Computer Aided Chemical Engineering

T3 - en_GB

SP - 715

EP - 719

ER -