A generic process template for continuous pharmaceutical production

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012


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In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.
Original languageEnglish
Title of host publicationProceedings of the 11th International Symposium on Process Systems Engineering
EditorsI.A. Karimi, Rajagopalan Srinivasan
PublisherElsevier Science
Publication date2012
StatePublished - 2012
Event11th International Symposium on Process Systems Engineering - , Singapore


Conference11th International Symposium on Process Systems Engineering
NameComputer - Aided Chemical Engineering
ISSN (Print)1570-7946

Bibliographical note

Presented by John M.Woodley.


  • Process template, API, Substrate adoption, Methodology, Pharmaceutical
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