A Generic Framework for Systematic Design of Process Monitoring and Control System for Crystallization Processes

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012


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A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen phosphate (KDP), for which the targeted CSD is defined and achieved in one- and two-dimensional schemes.
Original languageEnglish
Title of host publicationProceedings of the 22nd European Symposium on Computer Aided Process Engineering
Publication date2012


Conference22nd European Symposium on Computer Aided Process Engineering
CountryUnited Kingdom

Bibliographical note

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  • Crystallization, Generic crystallization modelling, Analytical CSD estimator, Response surface method, Design of process monitoring and control systems
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ID: 9854524