A Generic Framework for Systematic Design of Process Monitoring and Control System for Crystallization Processes

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012


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A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen phosphate (KDP), for which the targeted CSD is defined and achieved in one- and two-dimensional schemes.
Original languageEnglish
Title of host publicationProceedings of the 22nd European Symposium on Computer Aided Process Engineering
Publication date2012
StatePublished - 2012
Event22nd European Symposium on Computer Aided Process Engineering - London, United Kingdom


Conference22nd European Symposium on Computer Aided Process Engineering
CountryUnited Kingdom

Bibliographical note

Only on CD


  • Crystallization, Generic crystallization modelling, Analytical CSD estimator, Response surface method, Design of process monitoring and control systems
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ID: 9854524