A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

Publication: Research - peer-reviewJournal article – Annual report year: 2011

  • Author: Nielsen, Birgit M.

    Copenhagen University Hospital

  • Author: Nielsen, Marie M.

    Copenhagen University Hospital

  • Author: Jakobsen, Marianne U.

    Aarhus University Hospital

  • Author: Nielsen, Carina J.

    Copenhagen University Hospital

  • Author: Holst, Claus

    Copenhagen University Hospital

  • Author: Larsen, Thomas M.

    University of Copenhagen

  • Author: Bendsen, Nathalie T.

    University of Copenhagen

  • Author: Bysted, Anette

    Division of Food Chemistry, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860, Søborg, Denmark

  • Author: Leth, Torben

    Division of Food Chemistry, National Food Institute, Technical University of Denmark

  • Author: Hougaard, David M.

    Statens Serum Institute, Department of Clinical Biochemistry and Immunology

  • Author: Skogstrand, Kristin

    Statens Serum Institute, Department of Clinical Biochemistry and Immunology

  • Author: Astrup, Arne

    University of Copenhagen

  • Author: Sørensen, Thorkild I. A.

    Copenhagen University Hospital

  • Author: Jess, Tine

    Copenhagen University Hospital

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Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m2. Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10–90th percentile 0·0–1·0) and R-TFA intake of 0·9 g (10–90th percentile 0·4–1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.
Original languageEnglish
JournalBritish Journal of Nutrition
Publication date2011
Volume106
Issue8
Pages1245-1252
ISSN0007-1145
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 2

Keywords

  • CHD, Trans-fatty acids, Insulin sensitivity, Blood lipids, Abdominal obesity, Inflammation
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