## A Combined Mathematical-Physical Model of Laser-Induced Thermotherapy (LITT)

Publication: Research - peer-review › Article in proceedings – Annual report year: 2009

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**A Combined Mathematical-Physical Model of Laser-Induced Thermotherapy (LITT).** / Enevoldsen, Marie Sand; Skovgaard, Ove; Andersen, Peter E.

Publication: Research - peer-review › Article in proceedings – Annual report year: 2009

### Harvard

*Therapeutic Laser Applications and Laser-Tissue Interactions IV: Proceedings of SPIE.*vol. Vol. 7373., 10.1117/12.831933

### APA

*Therapeutic Laser Applications and Laser-Tissue Interactions IV: Proceedings of SPIE.*(Vol. Vol. 7373). 10.1117/12.831933

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### MLA

*Therapeutic Laser Applications and Laser-Tissue Interactions IV: Proceedings of SPIE.*2009. Available: 10.1117/12.831933

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TY - GEN

T1 - A Combined Mathematical-Physical Model of Laser-Induced Thermotherapy (LITT)

AU - Enevoldsen,Marie Sand

AU - Skovgaard,Ove

AU - Andersen,Peter E.

PY - 2009

Y1 - 2009

N2 - Laser{induced thermo therapy (LITT) is an alternative, gentle therapy of cancer. In this work a new computa- tional model (3D space and time) of LITT is presented. Using an arbitrary small number (<20) of optical ¯bers, multiple low energy laser light sources are applied internal to an arbitrary shaped tumor in the human liver. The power and position of each source can be chosen arbitrary. Each source is a spherical point source emitting light isotropically. The model consists of two, semi{coupled partial di®erential equations (PDEs) describing the light distribution and the heat absorption in the target tissue. Since water is a dominant tissue component in both the healthy liver and the malignant tumor the wavelength of the laser is chosen in the NIR area (1,064 nm). This is expected to form an absorption contrast in favor of the tumor leading to high temperature and damage of the tumor cells. The new, fast computational model presented here opens for the possibility of evaluating the outcome of LITT by inspection of temperature ¯elds, and comparing these to measured histological damage due to heating. This combination is promising when evaluating the result of LITT prior to the actual treatment.

AB - Laser{induced thermo therapy (LITT) is an alternative, gentle therapy of cancer. In this work a new computa- tional model (3D space and time) of LITT is presented. Using an arbitrary small number (<20) of optical ¯bers, multiple low energy laser light sources are applied internal to an arbitrary shaped tumor in the human liver. The power and position of each source can be chosen arbitrary. Each source is a spherical point source emitting light isotropically. The model consists of two, semi{coupled partial di®erential equations (PDEs) describing the light distribution and the heat absorption in the target tissue. Since water is a dominant tissue component in both the healthy liver and the malignant tumor the wavelength of the laser is chosen in the NIR area (1,064 nm). This is expected to form an absorption contrast in favor of the tumor leading to high temperature and damage of the tumor cells. The new, fast computational model presented here opens for the possibility of evaluating the outcome of LITT by inspection of temperature ¯elds, and comparing these to measured histological damage due to heating. This combination is promising when evaluating the result of LITT prior to the actual treatment.

KW - semi{coupled PDEs

KW - water contrast

KW - LITT

KW - liver metastasis

U2 - 10.1117/12.831933

DO - 10.1117/12.831933

M3 - Article in proceedings

VL - Vol. 7373

BT - Therapeutic Laser Applications and Laser-Tissue Interactions IV

T2 - Therapeutic Laser Applications and Laser-Tissue Interactions IV

ER -