[18F]Fluoride recovery via gaseous [18F]HF

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Acidification of target water with H2SO4 in a specially constructed glassy carbon/polyethylene apparatus allowed for recovery of up to 82% of [18F]fluoride as [18F]HF gas. The [18F]HF distillate was found to be acid-free but moist; when passed through a solution of tBuPh2SiOTf, it yielded [18F]tBuPh2SiF. The multivariate design of experiment showed that the key to high yield of [18F]HF was the efficient degassing of the reaction mixture.
Original languageEnglish
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Publication date2011
Volume54
Journal number13
Pages816
ISSN0362-4803
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 2

Keywords

  • Hevesy laboratory
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