- Danish Cancer Society, Denmark
- University of Copenhagen, Denmark
Alcohol is an important risk factor for breast cancer, especially in Denmark, where women have a high alcohol intake and a high breast cancer incidence. We have found that PPARg activity is associated with a high rate of alcohol related breast cancer whereas genetically determined low PPARg activity confers protection against alcohol related breast cancer among postmenopausal women. In postmenopausal women, estrogens are synthesized in the adipose tissue. Adipocyte steroid synthesis is inhibited by PPARg. We believe that alcohol intake modifies a PPARg dependent regulation of estrogen biosynthesis. The present application aims at establishing whether PPARg activity is a determinant for alcohol related breast cancer. It is very important to clarify this relationship, since several types of medication including over-the-counter medication may enhance alcohol related breast cancer through activation of PPARg.
|Period||01/05/09 → 01/12/11|