- University of Southern Denmark, Denmark
The overall aim is to investigate and compare three widely used azole fungicides potential interaction with the endocrine system (sex and thyroid hormones) including effects on brain development. Azole fungicides are used for the control of fungal infections in cereals and on fruit and vegetables. In general these fungicides are having a low acute toxicity, but only little is known on potential adverse health effects after prolonged exposure to low levels. Recently, we showed that the azole fungicide, prochloraz, is having multiple mechanisms of action and that the compound causes feminization of the male rat offspring after perinatal exposure. In this project the most widely used azoles in Denmark (epoxyconazole, tebuconazole and propiconazole) will be evaluated for their effects in vitro on the estrogen, androgen, and the Ah receptor as well as their effects on aromatase activity, sex hormone synthesis and thyroid receptor-mediated proliferation. In vivo experiments are conducted to evaluate any feminizing effects on rat male pups after gestational and lactational exposure. The results will provide new knowledge on the toxic mechanisms of action of the azole fungicides and their potential adverse effects on the reproductive system and on brain development and is therefore expected to contribute to a better risk assessment of these fungicides.
|Period||01/01/05 → 31/12/08|