Zoltan Imre Szallasi

  1. 2014
  2. Published

    Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution. / Dewhurst, Sally M.; McGranahan, Nicholas; Burrell, Rebecca A.; Rowan, Andrew J.; Grönroos, Eva; Endesfelder, David; Joshi, Tejal; Mouradov, Dmitri; Gibbs, Peter; Ward, Robyn L.; Hawkins, Nicholas J.; Szallasi, Zoltan Imre; Sieber, Oliver M.; Swanton, Charles.

    In: Cancer Discovery, Vol. 4, No. 2, 2014, p. 175-185.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  3. 2013
  4. Published

    31P gain of chromosomal region 15q26 cause increased expression of blm and fanci, and is associated with sensitivity to platinum chemotherapy in triple negative breast cancer. / Birkbak, Nicolai Juul; Li, Y.; Bowman-Collin, C.; Iglehart, J.D.; Silver, D.; Wang, Z.C.; Szallasi, Zoltan Imre; Richardson, A.

    In: Annals of Oncology, Vol. 24, No. suppl 3, 2013, p. iii22.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  5. Published
  6. Published

    Biasogram: visualization of confounding technical bias in gene expression data.. / Krzystanek, Marcin; Szallasi, Zoltan Imre; Eklund, Aron Charles.

    In: P L o S One, Vol. 8, No. 4, 2013, p. e61872.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  7. Published

    Deconvoluting complex tissues for expression quantitative trait locus-based analyses. / Seo, Ji-Heui; Li, Qiyuan; Fatima, Aquila; Eklund, Aron Charles; Szallasi, Zoltan Imre; Polyak, Kornelia; Richardson, Andrea L.; Freedman, Matthew L.

    In: Royal Society of London. Philosophical Transactions B. Biological Sciences, Vol. 368, No. 1620, 2013, p. 20120363-20120363.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  8. Published

    Methods for predicting anti-cancer response. / Szallasi, Zoltan Imre (Inventor); Eklund, Aron Charles (Inventor); Birkbak, Nicolai Juul (Inventor); Richardson, Andrea L. (Inventor); Silver, Daniel P. (Inventor); Wang, Zhigang (Inventor).

    IPC No.: C12Q1/68. Sep 06, 2013.

    Publication: ResearchPatent – Annual report year: 2013

  9. Published

    Parallel evolution of tumor subclones mimics diversity between tumors. / Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco; McGranahan, Nicholas; Burrell, Rebecca; Rowan, Andrew; Joshi, Tejal; Fisher, Rosalie; Larkin, James; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Journal of Pathology, Vol. 230, No. 4, 2013, p. 356-364.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  10. Published

    Prognostic and Predictive Markers in Metastatic Renal Cell Carcinoma. / Khattak, Muhammad A.; Bakr, Farrah; Krzystanek, Marcin; Szallasi, Zoltan Imre; Gerlinger, Marco; Santos, Claudio; Swanton, Charles; Pickering, Lisa M.; Gore, Martin E.; Larkin, James M.G.

    In: Journal of Clinical Oncology, Vol. 31, No. 7, 2013, p. 20971-972.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  11. Published

    The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.. / Szász, Attila Marcell; Li, Qiyuan; Eklund, Aron Charles; Sztupinszki, Zsófia; Rowan, Andrew; Tőkés, Anna-Mária; Székely, Borbála; Kiss, András; Szendrői, Miklós; Győrffy, Balázs; Szallasi, Zoltan Imre; Swanton, Charles; Kulka, Janina.

    In: PloS one., Vol. 8, No. 2, 2013, p. e56707.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  12. Published

    Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations. / Birkbak, Nicolai Juul; Kochupurakkal, Bose; Gonzalez-Izarzugaza, Jose Maria; Eklund, Aron Charles; Li, Yang; Liu, Joyce; Szallasi, Zoltan Imre; Matulonis, Ursula A. ; Richardson, Andrea L. ; Iglehart, J. Dirk ; Wang, Zhigang C.

    In: P L o S One, Vol. 8, No. 11, e80023, 2013.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  13. 2012
  14. Published

    CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction. / Lee, Alvin J. X.; Roylance, Rebecca; Sander, Jil; Gorman, Patricia; Endesfelder, David; Kschischo, Maik; Jones, Neil P.; East, Philip; Nicke, Barbara; Spassieva, Stefka; Obeid, Lina M.; Birkbak, Nicolai Juul; Szallasi, Zoltan; McKnight, Nicole C.; Rowan, Andrew J.; Speirs, Valerie; Hanby, Andrew M.; Downward, Julian; Tooze, Sharon A.; Swanton, Charles.

    In: Journal of Pathology, Vol. 226, No. 3, 2012, p. 482-494.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  15. Published

    Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. / Győrffy, Balázs; Lánczky, András; Szállási, Zoltán.

    In: Endocrine - Related Cancer, Vol. 19, No. 2, 2012, p. 197-208.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  16. Published

    Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James; Endesfelder, David; Gronroos, Eva; Martinez, Pierre; Matthews, Nicholas; Stewart, Aengus; Tarpey, Patrick; Varela, Ignacio; Phillimore, Benjamin; Begum, Sharmin; McDonald, Neil Q.; Butler, Adam; Jones, David; Raine, Keiran; Latimer, Calli; Santos, Claudio R.; Nohadani, Mahrokh; Eklund, Aron Charles; Spencer-Dene, Bradley; Clark, Graham; Pickering, Lisa; Stamp, Gordon; Gore, Martin; Szallasi, Zoltan Imre; Downward, Julian; Futreal, P. Andrew; Swanton, Charles.

    In: New England Journal of Medicine, Vol. 366, No. 10, 2012, p. 883-892.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  17. Published

    Parallel Evolution under Chemotherapy Pressure in 29 Breast Cancer Cell Lines Results in Dissimilar Mechanisms of Resistance. / Tegze, Balint; Szallasi, Zoltan Imre; Haltrich, Iren; Penzvalto, Zsofia; Toth, Zsuzsa; Liko, Istvan; Gyoerffy, Balazs.

    In: P L o S One, Vol. 7, No. 2, 2012, p. e30804.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  18. Published

    Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents. / Birkbak, Nicolai J.; Wang, Zhigang C.; Kim, Ji-Young; Eklund, Aron C.; Li, Qiyuan; Tian, Ruiyang; Bowman-Colin, Christian; Li, Yang; Greene-Colozzi, April; Iglehart, J. Dirk; Tung, Nadine; Ryan, Paula D.; Garber, Judy E.; Silver, Daniel P.; Szallasi, Zoltan; Richardson, Andrea L.

    In: Cancer Drug Discovery and Development, Vol. 2, No. 4, 2012, p. 366-375.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  19. 2011
  20. Published

    Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer. / Roylance, Rebecca; Endesfelder, David; Gorman, Patricia; Sander, Jil; Tomlinson, Ian; M. Hanby, Andrew; Speirs, Valerie; L. Richardson, Andrea; Birkbak, Nicolai Juul; Eklund, Aron Charles; Downward, Julian; Kschischo, Maik; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Cancer Epidemiology, Biomarkers & Prevention, 22.07.2011, p. 2184-2197.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  21. Published

    A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.. / Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul; Szallasi, Zoltan Imre; Kschischo, Maik; A. Graham, Trevor; Swanton, Charles.

    In: OncoTarget, 2011.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  22. Published

    Chromosomal Instability Confers Intrinsic Multidrug Resistance. / Lee, Alvin J. X.; Endesfelder, David; Rowan, Andrew J.; Walther, Axel; Birkbak, Nicolai Juul; Futreal, P. Andrew; Downward, Julian; Szallasi, Zoltan Imre; Tomlinson, Ian P. M.; Howell, Michael; Kschischo, Maik; Swanton, Charles.

    In: Cancer Research, Vol. 71, No. 5, 2011, p. 1858-1870.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  23. Published

    Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response. / Li, Qiyuan; Eklund, Aron Charles; Birkbak, Nicolai Juul; Desmedt, Christine; Haibe-Kains, Benjamin; Sotiriou, Christos; Symmans, W. Fraser; Pusztai, Lajos; Brunak, Søren; Richardson, Andrea L; Szallasi, Zoltan Imre.

    In: B M C Bioinformatics, Vol. 12, No. 1, 2011, p. 310.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  24. Published

    Jetset: selecting the optimal microarray probe set to represent a gene. / Li, Qiyuan; Birkbak, Nicolai Juul; Gyorffy, Balazs; Szallasi, Zoltan Imre; Eklund, Aron Charles.

    In: B M C Bioinformatics, Vol. 12, No. 1, 2011, p. 474.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  25. Published

    Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer. / Birkbak, Nicolai Juul; Eklund, Aron Charles; Li, Qiyuan; McClelland, Sarah E.; Endesfelder, David; Tan, Patrick; Tan, Iain B.; Richardson, Andrea L.; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Cancer Research, Vol. 71, No. 10, 2011, p. 3447-3452.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  26. Published
  27. 2010
  28. Published

    A focused, PCR based gene expression signature to refine grade in breast cancer. / Szasz, A.; Tokes, A. M.; Szittya, L.; Baranyak, Z. S.; Szekely, B.; Eklund, Aron Charles; Li, Qiyuan; Swanton, C.; Szallasi, Zoltan Imre; Kulka, J.

    In: EJC SUPPLEMENTS, Vol. 8, No. 3, 2010, p. 226-226.

    Publication: ResearchConference abstract in journal – Annual report year: 2010

  29. Published

    Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. / Szallasi, Zoltan Imre; Li, Yang; Zou, Lihua; Li, Qiyuan; Haibe-Kains, Benjamin; Tian, Ruiyang; Li, Yan; Desmedt, Christine; Sotiriou, Christos; Iglehart, J Dirk; Richardson, Andrea L; Wang, Zhigang Charles.

    In: Nature Medicine, Vol. 16, No. 2, 2010, p. 214-218.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  30. Published

    An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. / Györffy, B; Lanczky, A; Eklund, Aron Charles; Denkert, Carsten; Budczies, J; Li, Qiyuan; Szallasi, Zoltan Imre.

    In: Breast Cancer Research and Treatment, Vol. 123, No. 3, 2010, p. 725-731.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  31. Published

    Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials. / Juul, Nicolai Stefan; Szallasi, Zoltan Imre; Eklund, Aron Charles; Li, Qiyuan; Burrell, RA; Gerlinger, M; Valero, V; Andreopoulou, E; Esteva, FJ; Symmans, WF; Desmedt, C; Haibe-Kains, B; Sotiriou, C; Pusztai, L; Swanton, C.

    In: Lancet Oncology, Vol. 11, No. 4, 2010, p. 358-365.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  32. Published

    Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer. / Szallasi, Zoltan Imre; Eklund, Aron Charles; Li, Qiyuan; Juul, Nicolai Stefan; Silver, Daniel P.; Richardson, Andrea L.; Wang, Zhigang C.; Leong, Chee-Onn; Calogrias, Diana; Buraimoh, Ayodele; Fatima, Aquila; Gelman, Rebecca S.; Ryan, Paula D.; Tung, Nadine M.; De Nicolo, Arcangela; Ganesan, Shridar; Miron, Alexander; Colin, Christian; Sgroi, Dennis C.; Ellisen, Leif W.; Winer, Eric P.; Garber, Judy E.

    In: Journal of Clinical Oncology, Vol. 28, No. 7, 2010, p. 1145-1153.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  33. Published

    Minimising Immunohistochemical False Negative ER Classification Using a Complementary 23 Gene Expression Signature of ER Status. / Li, Qiyuan; Eklund, Aron Charles; Birkbak, Nicolai Juul; Haibe-Kains, B.; Workman, Christopher; Richardson, A.L.; Szallasi, Zoltan Imre; Swanton, C.

    In: P L o S One, Vol. 5, No. 12, 2010.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  34. Published
  35. Published

    Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. / Swanton, C.; Larkin, J.M.; Gerlinger, M.; Eklund, Aron Charles; Howell, M.; Stamp, G.; Downward, J.; Gore, M.; Futreal, P.A.; Escudier, B.; Andre, F.; Albiges, L.; Beuselinck, B.; Oudard, S.; Hoffmann, J.; Gyorffy, B.; Torrance, C.; Boehme, K.A.; Volkmer, H.; Toschi, L.; Nicke, B.; Beck, Marlene; Szallasi, Zoltan Imre.

    In: Genome Medicine, Vol. 2, No. 8, 2010.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  36. Published

    Targeting Chromosomal Instability and Tumour Heterogeneity in HER2-Positive Breast Cancer. / Burrell, Rebecca A.; Birkbak, Nicolai Juul; Johnston, Stephen R.; Reis-Filho, Jorge S.; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Journal of Cellular Biochemistry, Vol. 111, No. 4, 2010, p. 782-790.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  37. 2009
  38. Published

    A Functional Metagene Incorporating TTK Protein Kinase, Aurora Kinase B and Glucosylceramide Synthase Predicts Response to Treatment in Primary Breast Cancer. / Juul, Nicolai Stefan; Eklund, Aron Charles; Li, Qiyuan; Downward, J.; Burrell, R.; Szallasi, Zoltan Imre; Swanton, C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 602S-602S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  39. Published

    A Genomic-Profile Derived Summary Measure of Chromosomal Breakpoints Predicts Response to Treatment with the DNA-Damaging Agent Cisplatin.. / Juul, Nicolai Stefan; Wang, Y; Kim, JY; Eklund, Aron Charles; Li, Qiyuan; Carlton, VEH; Gerlinger, M; Swanton, C; Garber, JE; Silver, DP; Faham, M; Richardson, A. L; Szallasi, Zoltan Imre; Wang, Z. C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 509S-510S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  40. Published

    Chromosomal instability determines taxane response. / Swanton, C.; Nicke, B.; Schuett, M.; Eklund, Aron Charles; Ng, C.; Li, Q.Y.; Hardcastle, T.; Lee, A.; Roy, R.; East, P.; Kschischo, M.; Endesfelder, D.; Wylie, P.; Kim, S. N.; Chen, J. G.; Howell, M.; Ried, T.; Habermann, J.K.; Auer, G.; Brenton, J. D.; Szallasi, Zoltan Imre; Downward, J.

    In: National Academy of Sciences. Proceedings, Vol. 106, No. 21, 2009, p. 8671-8676.

    Publication: Research - peer-reviewJournal article – Annual report year: 2009

  41. Published

    Computational Dissection of Tumor Expression Profiles. / Eklund, Aron Charles; Juul, Nicolai Stefan; Li, Qiyuan; Richardson, A. L; Szallasi, Zoltan Imre.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 591S-591S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  42. Published

    Consistent Principal Components from Triple Negative Breast Cancer Expression Profiles Yields Agent Specific Predictors of Chemotherapy Response. / Li, Qiyuan; Eklund, Aron Charles; Juul, Nicolai Stefan; Desmedt, C; Haibe-Kain, B; Sotiriou, C; Symmans, W. F.; Pusztai, L; Richardson, A. L.; Szallasi, Zoltan Imre.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 700S-700S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  43. Published

    Evaluation of Microarray Preprocessing Algorithms Based on Concordance with RT-PCR in Clinical Samples. / Hansen, Kasper Lage; Szallasi, Zoltan Imre; Eklund, Aron Charles; Gyorffy, B; Molnar, B.

    In: P L o S One, Vol. 4, No. 5, 2009, p. e5645.

    Publication: Research - peer-reviewJournal article – Annual report year: 2009

  44. Published
  45. Published

    Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo. / Burrell, R.A.; McClelland, S.E.; Juul, Nicolai Stefan; Downward, J.; Szallasi, Zoltan Imre; Swanton, C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 641S-641S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  46. 2008
  47. Published
  48. Published

    Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure. / Lee, A.J.X.; East, P.; Pepper, S.; Nicke, B.; Szallasi, Zoltan Imre; Eklund, Aron Charles; Downward, J.; Swanton, C.

    In: Cell Cycle, Vol. 7, No. 24, 2008, p. 3947-3948.

    Publication: Research - peer-reviewJournal article – Annual report year: 2008

  49. Published

    Correction of technical bias in clinical microarray data improves concordance with known biological information. / Eklund, Aron Charles; Szallasi, Zoltan Imre.

    In: Genome Biology, Vol. 9, No. 2, 2008, p. R26.

    Publication: Research - peer-reviewJournal article – Annual report year: 2008

  50. Published

    Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. / Swanton, Charles; Szallasi, Zoltan Imre; Brenton, James D.; Downward, Julian.

    In: Breast Cancer Research (Online Edition), Vol. 10, No. 5, 2008, p. 214.

    Publication: Research - peer-reviewJournal article – Annual report year: 2008

  51. 2006
  52. Published

    A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. / Carter, SL; Eklund, AC; Kohane, IS; Harris, LN; Szallasi, Zoltan Imre.

    In: NATURE GENETICS, Vol. 38, 2006, p. 1043-1048.

    Publication: Research - peer-reviewJournal article – Annual report year: 2006

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