My main areas of work are QSAR and PBTK modelling:

- (Quantitative) Structure Activity Relationships ((Q)SARs) are the relationships between the structural properties of chemical substances and another property e.g. a physico-chemical property or a biological activity, including the ability to cause toxic effects. QSAR models can be used to predict properties of substances for which there are lack of experimental data. Thereby the models can reduce the number of animal tests necessary in the assessment of chemical substances, increase the information for a given substance (including metabolites and degradation products), and save companies and authorities time and money. In the EU legislation, REACH, it is expected that (Q)SARs will be used as a direct replacement for test data as relevant and reliable models become increasingly available, and as experience in their use becomes more widespread.
 

- In a physiologically based toxicokinetic (PBTK) model the animal or man is described as a set of tissue compartments which is combined by mathematical descriptions of biological tissues and physiological processes in the body. Thereby it is possible to quantitatively simulate the absorption, distribution, metabolism and excretion of chemicals and to predict the internal dose after exposure to the chemical (or its metabolite) of concern which can be useful in the risk assessment.

CV

Academic grades

M.Sc., environmental chemistry

Ph.D.

Professional experience

2007 - 2012 Ph.D. student - DTU Food, Division of Toxicology and Risk Assessment
1999 - Toxicologist (T) - DTU Food, Dept. of Toxicology and Risk assessment

Expertise

My main areas of work are QSAR and PBTK modelling:

- (Quantitative) Structure Activity Relationships ((Q)SARs) are the relationships between the structural properties of chemical substances and another property e.g. a physico-chemical property or a biological activity, including the ability to cause toxic effects. QSAR models can be used to predict properties of substances for which there are lack of experimental data. Thereby the models can reduce the number of animal tests necessary in the assessment of chemical substances, increase the information for a given substance (including metabolites and degradation products), and save companies and authorities time and money. In the EU legislation, REACH, it is expected that (Q)SARs will be used as a direct replacement for test data as relevant and reliable models become increasingly available, and as experience in their use becomes more widespread.

- In a physiologically based toxicokinetic (PBTK) model the animal or man is described as a set of tissue compartments which is combined by mathematical descriptions of biological tissues and physiological processes in the body. Thereby it is possible to quantitatively simulate the absorption, distribution, metabolism and excretion of chemicals and to predict the internal dose after exposure to the chemical (or its metabolite) of concern which can be useful in the risk assessment.

My links

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  • Toxicology Letters

    ISSNs: 0378-4274, 0378-4274

    Elsevier Ireland Ltd, Ireland

    ISI indexed (2013): ISI indexed yes, BFI (2015): BFI-level 1, Scopus rating (2015): 1.267 1.072

    Central database

    Journal

  • Chemical Research in Toxicology

    ISSNs: 0893-228X

    Additional searchable ISSN (Electronic): 1520-5010

    American Chemical Society, United States

    ISI indexed (2013): ISI indexed yes, BFI (2015): BFI-level 1, Scopus rating (2015): 1.323 1.137

    Central database

    Journal

  • International Journal of Environmental Analytical Chemistry

    ISSNs: 0306-7319

    Additional searchable ISSN (Electronic): 1026-7468

    Taylor & Francis Ltd., United Kingdom

    ISI indexed (2013): ISI indexed yes, BFI (2015): BFI-level 1, Scopus rating (2015): 0.425 0.514

    Central database

    Journal

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