Reactor and Process Design for Multi-enzymatic Synthesis

Enzyme cascades (which mimic nature) using two or more enzymes sequentially for the synthesis of useful chemical compounds are attracting increasing interest as a potential means of production. Such schemes overcome many of the conventional problems integrating biocatalysis into chemical synthetic schemes, such as changes of media, temperature and pH. In this project, the synthesis of sialic acid derivatives and useful oligosaccharides will be taken as an example for the design of an enzyme cascade. Laboratory scale-down tests will be carried out to characterize the enzymatic systems. Engineering tools for selection of reactors and processes for multi-enzymatic synthesis will be developed.

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  • Bioresource Technology

    ISSNs: 0960-8524, 09608524

    ISSNs (Electronic): 1873-2976

    Elsevier BV, Netherlands

    ISI indexed (2013): yes, FI (2013): 2

    Central database


  • Protein Engineering Design and Selection (Print)

    ISSNs: 1741-0126

    ISSNs (Electronic): 1741-0134

    Oxford University Press, United Kingdom

    ISI indexed (2013): yes, FI (2013): 1

    Central database


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