Niels Hadrup

Niels Hadrup

Researcher

Mørkhøj Bygade 19, Building G, Room 114

2860 Søborg

Denmark

Phone: 35887595

Fax: 35887595

My research areas are:

 

1. Mixture toxicology

I am work package leader in a four year project investigating mathematical models used to assess toxicological effects of chemical mixtures. The results obtained in this project will most likely be utilized in future toxicological risk assessment of chemical mixtures.

 

I have one published article in this area and several under way.

 

Concentration addition, independent action and generalized concentration addition models for mixture effect prediction of sex hormone synthesis in vitro.

Hadrup N, Taxvig C, Pedersen M, Nellemann C, Hass U, Vinggaard AM.

PLoS One. 2013 Aug 22;8(8):e70490. doi: 10.1371/journal.pone.0070490. eCollection 2013.

 

I was also co-author of the European Food Safety Authority project: "Identification of cumulative assessment groups of pesticides", which can be found at:

http://www.efsa.europa.eu/en/supporting/pub/269e.htm

 

2. Nanoparticle toxicology, specifically silver ions and silver nanoparticles.

I have several publications in this area including one review article:

 

Oral toxicity of silver ions, silver nanoparticles and colloidal silver--a review.

Hadrup N, Lam HR.

Regul Toxicol Pharmacol. 2014 Feb;68(1):1-7. doi: 10.1016/j.yrtph.2013.11.002. Epub 2013 Nov 12. 

 

 

 

3. New methods for assessing toxicity of chemicals

I work at setting up models for better assessment of toxicity in general. I use such mechanistic techniues as pharmacological modulation e.g. with inhibitors or activators to shut down or modulate specific pathways in the mammalian body; I do Western blotting to assess protein levels of specific proteins as well as mRNA and immunonohistochemistry techniques. The use of metabolomics as a new tool for this is also a focus area.

CV

Education

1995 - 1998 Bachelor level in biology - University of Aarhus
1998 - 2001 MSc (human biology) - University of Copenhagen, Faculty of Health
2002 - 2005 PhD study - University of Copenhagen, Department of Pharmacology

Academic grades

MSc (human biology), PhD

Professional experience

2001 - 2002 Research assistant - University of Copenhagen, Pharmacology
2002 - 2005 PhD study - University of Copenhagen
2005 - 2008 Post Doc - Radboud University / Leiden University Medical Center, Netherlands
2008 - 2010 Post Doc - DTU Food
2011 - Researcher - DTU Food

Languages

English, Danish, German, Dutch

Expertise

Mixture toxicology

Nanoparticle toxicology

Kidney pharmacology and toxicology

In vivo and in vitro techniques

The use of metabolomic techniques for toxicity investigations

Silver (nanoparticles and ions).

International experience

I have two years of postdoc experience in kidney physiology, pharmacology and immunology from Radboud University, Nijmegen and Leiden University Medical Center in the Netherlands

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Activities

(11)

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  • Toxicology Letters

    ISSNs: 0378-4274, 03784274

    Elsevier Ireland Ltd, Ireland

    FI (2013): 1, ISI indexed (2013): yes

    Central database

    Journal

  • American Journal of Physiology: Renal Physiology

    ISSNs: 1931-857X, 0363-6127, 1931857x

    American Physiological Society, United States

    FI (2013): 2, ISI indexed (2013): yes

    Central database

    Journal

  • Reproductive Toxicology

    ISSNs: 0890-6238, 08906238

    Elsevier Inc., United States

    FI (2013): 2, ISI indexed (2013): yes

    Central database

    Journal

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