Nicolai Juul Birkbak

  1. 2015
  2. Published

    Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. / McGranahan, Nicholas; Favero, Francesco; de Bruin, Elza C.; Birkbak, Nicolai Juul; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Science Translational Medicine, Vol. 7, No. 283, 283ra54, 2015.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  3. Published

    Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome. / Favero, Francesco; McGranahan, Nicholas; Salm, Maximilian P.; Birkbak, Nicolai Juul; Sanborn, J. Zachary ; Benz, Stephen C. ; Becq, Jennifer; Peden, John F. ; Kingsbury, Zoya ; Grocok, Russell J. ; Eklund, Aron Charles.

    In: Annals of Oncology, Vol. 26, No. 5, 2015, p. 880-887.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  4. Published
  5. 2014
  6. Published

    A pan-cancer analysis of inferred homologous recombination deficiency identifies potential platinum benefit in novel subtypes. / Marquard, Andrea Marion; Eklund, Aron Charles; Wang, Zhigang C.; Richardson, Andrea L.; Szallasi, Zoltan Imre; Birkbak, Nicolai Juul.

    In: Cancer Research, Vol. 74, No. 19 - Supplement, 2822, 2014.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2015

  7. Published

    Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?. / Shi, Leming; Haibe-Kains, Benjamin; Birkbak, Nicolai Juul; Bedard, Philippe L.; Hatzis, Christos; Stern, David F.; Clarke, Robert; Quackenbush, John; Beck, Andrew H.; Aerts, Hugo J. W. L.

    In: Cancer Research, Vol. 74, No. 15, 2014, p. 4016-4023.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  8. Published

    Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer.. / Roylance, Rebecca; Endesfelder, David; Jamal-Hanjani, Mariam; Burrell, Rebecca A.; Gorman, Patricia; Sander, Jil; Murphy, Niamh; Birkbak, Nicolai Juul; Hanby, Andrew M.; Speirs, Valerie; Johnston, Stephen R. D.; Kschischo, Maik; Swanton, Charles.

    In: Breast Cancer Research and Treatment, Vol. 148, No. 1, 2014, p. 221-229.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  9. Published

    Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection. / Christensen, Dan Ploug; Gysemans, Conny; Lundh, Morten; Dahllöf, Mattias Salling; Noesgaard, Daniel; Schmidt, Søren Fisker; Mandrup, Susanne; Birkbak, Nicolai Juul; Workman, Christopher; Piemonti, Lorenzo; Blaabjerg, Lykke; Monzani, Valmen; Fossati, Gianluca; Mascagni, Paolo; Paraskevas, Steven; Aikin, Reid A.; Billestrup, Nils; Grunnet, Lars Groth; Dinarello, Charles A.; Mathieu, Chantal; Mandrup-Poulsen, Thomas.

    In: National Academy of Sciences. Proceedings, Vol. 111, No. 3, 2014, p. 1055-1059.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  10. STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes. / Xiang, Michael; Birkbak, Nicolai Juul; Vafaizadeh, Vida; Walker, Sarah R. ; Yeh, Jennifer E. ; Liu, Suhu; Kroll, Yasmin; Boldin, Mark; Taganov, Konstantin; Groner, Bernd; Richardson, Andrea L.; Frank, David A. .

    In: Science Signaling, Vol. 7, No. 310, 2014.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  11. Published

    Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers. / Gulati, Sakshi; Martinez, Pierre; Joshi, Tejal; Birkbak, Nicolai Juul; Santos, Claudio R.; Rowan, Andrew J.; Pickering, Lisa; Gore, Martin; Larkin, James; Szallasi, Zoltan Imre; Bates, Paul A.; Swanton, Charles; Gerlinger, Marco.

    In: European Urology, Vol. 66, No. 5, 2014, p. 936-948.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  12. Published

    Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study. / Jamal-Hanjani, Mariam; Hackshaw, Alan; Ngai, Yenting; Shaw, Jacqueline; Dive, Caroline; Quezada, Sergio; Middleton, Gary; de Bruin, Elza; Le Quesne, John; Shafi, Seema; Falzon, Mary; Horswell, Stuart; Blackhall, Fiona; Khan, Iftekhar; Janes, Sam; Nicolson, Marianne; Lawrence, David; Forster, Martin; Fennell, Dean; Lee, Siow-Ming; Lester, Jason; Kerr, Keith; Muller, Salli; Iles, Natasha; Smith, Sean; Murugaesu, Nirupa; Mitter, Richard; Salm, Max; Stuart, Aengus; Matthews, Nik; Adams, Haydn; Ahmad, Tanya; Attanoos, Richard; Bennett, Jonathan; Birkbak, Nicolai Juul; Booton, Richard; Brady, Ged; Buchan, Keith; Capitano, Arrigo; Chetty, Mahendran; Cobbold, Mark; Crosbie, Philip; Davies, Helen; Denison, Alan; Djearman, Madhav; Goldman, Jacki; Haswell, Tom; Joseph, Leena; Kornaszewska, Malgorzata; Krebs, Matthew; Langman, Gerald; MacKenzie, Mairead; Millar, Joy; Morgan, Bruno; Naidu, Babu; Nonaka, Daisuke; Peggs, Karl; Pritchard, Catrin; Remmen, Hardy; Rowan, Andrew; Shah, Rajesh; Smith, Elaine; Summers, Yvonne; Taylor, Magali; Veeriah, Selvaraju; Waller, David; Wilcox, Ben; Wilcox, Maggie; Woolhouse, Ian; McGranahan, Nicholas; Swanton, Charles.

    In: P L o S Biology, Vol. 12, No. 7, e1001906, 2014.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  13. 2013
  14. Published

    31P gain of chromosomal region 15q26 cause increased expression of blm and fanci, and is associated with sensitivity to platinum chemotherapy in triple negative breast cancer. / Birkbak, Nicolai Juul; Li, Y.; Bowman-Collin, C.; Iglehart, J.D.; Silver, D.; Wang, Z.C.; Szallasi, Zoltan Imre; Richardson, A.

    In: Annals of Oncology, Vol. 24, No. suppl 3, 2013, p. iii22.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  15. Published
  16. Published

    Computational optimisation of targeted DNA sequencing for cancer detection.. / Martinez, Pierre; McGranahan, Nicholas; Birkbak, Nicolai Juul; Gerlinger, Marco; Swanton, Charles.

    In: Scientific Reports, Vol. 3, 2013, p. 3309.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  17. Published

    Exome mutation burden predicts clinical outcome in ovarian cancer carrying mutated BRCA1 and BRCA2 genes. / Birkbak, Nicolai Juul; Kochupurakkal, Bose; Gonzalez-Izarzugaza, Jose Maria; Li, Yang; Liu, Joyce; Szallasi, Zoltan Imre; Matulonis, Ursula; Richardson, Andrea L.; Iglehart, J. Dirk; Wang, Zhigang C.

    In: Cancer Research, Vol. 73, No. S1, 2013.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2014

  18. Published

    HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. / Adelman, Carrie A.; Lolo, Rafal L.; Birkbak, Nicolai Juul; Murina, Olga; Matsuzaki, Kenichiro; Horejsi, Zuzana; Parmar, Kalindi; Borel, Valérie; Skehel, J. Mark; Stamp, Gordon; D'Andrea, Alan; Sartori, Alessandro A; Swanton, Charles; Boulton, Simon J.

    In: Nature, Vol. 502, 2013, p. 381-384.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  19. Published

    Inconsistency in large pharmacogenomic studies. / Haibe-Kains, Benjamin; El-Hachem, Nehme; Birkbak, Nicolai Juul; Jin, Andrew C.; Beck, Andrew H; Aerts, Hugo J. W. L.; Quackenbush, John.

    In: Nature, Vol. 504, No. 7480, 2013, p. 389–393.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  20. Published

    Methods for predicting anti-cancer response. / Szallasi, Zoltan Imre (Inventor); Eklund, Aron Charles (Inventor); Birkbak, Nicolai Juul (Inventor); Richardson, Andrea L. (Inventor); Silver, Daniel P. (Inventor); Wang, Zhigang (Inventor).

    IPC No.: C12Q1/68. Patent No.: WO2013130347. Sep 06, 2013.

    Publication: ResearchPatent – Annual report year: 2012

  21. Published

    Parallel evolution of tumor subclones mimics diversity between tumors. / Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco; McGranahan, Nicholas; Burrell, Rebecca; Rowan, Andrew; Joshi, Tejal; Fisher, Rosalie; Larkin, James; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Journal of Pathology, Vol. 230, No. 4, 2013, p. 356-364.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  22. Published

    Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations. / Birkbak, Nicolai Juul; Kochupurakkal, Bose; Gonzalez-Izarzugaza, Jose Maria; Eklund, Aron Charles; Li, Yang; Liu, Joyce; Szallasi, Zoltan Imre; Matulonis, Ursula A. ; Richardson, Andrea L. ; Iglehart, J. Dirk ; Wang, Zhigang C.

    In: P L o S One, Vol. 8, No. 11, e80023, 2013.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  23. 2012
  24. Published

    CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction. / Lee, Alvin J. X.; Roylance, Rebecca; Sander, Jil; Gorman, Patricia; Endesfelder, David; Kschischo, Maik; Jones, Neil P.; East, Philip; Nicke, Barbara; Spassieva, Stefka; Obeid, Lina M.; Birkbak, Nicolai Juul; Szallasi, Zoltan; McKnight, Nicole C.; Rowan, Andrew J.; Speirs, Valerie; Hanby, Andrew M.; Downward, Julian; Tooze, Sharon A.; Swanton, Charles.

    In: Journal of Pathology, Vol. 226, No. 3, 2012, p. 482-494.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  25. Published

    Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome. / Wang, Zhigang C.; Birkbak, Nicolai Juul; Culhane, Aedín C.; Drapkin, Ronny; Fatima, Aquila; Tian, Ruiyang; Schwede, Matthew; Alsop, Kathryn; Daniels, Kathryn E.; Piao, Huiying; Liu, Joyce; Etemadmoghadam, Dariush; Miron, Alexander; Salvesen, Helga B.; Mitchell, Gillian; DeFazio, Anna; Quackenbush, John; Berkowitz, Ross S.; Iglehart, J. Dirk; Bowtell, David D.L.; Matulonis, Ursula A.

    In: Clinical Cancer Research, Vol. 18, No. 20, 2012, p. 5806-5815.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  26. Published

    Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents. / Birkbak, Nicolai J.; Wang, Zhigang C.; Kim, Ji-Young; Eklund, Aron C.; Li, Qiyuan; Tian, Ruiyang; Bowman-Colin, Christian; Li, Yang; Greene-Colozzi, April; Iglehart, J. Dirk; Tung, Nadine; Ryan, Paula D.; Garber, Judy E.; Silver, Daniel P.; Szallasi, Zoltan; Richardson, Andrea L.

    In: Cancer Drug Discovery and Development, Vol. 2, No. 4, 2012, p. 366-375.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  27. 2011
  28. Published

    Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer. / Roylance, Rebecca; Endesfelder, David; Gorman, Patricia; Sander, Jil; Tomlinson, Ian; M. Hanby, Andrew; Speirs, Valerie; L. Richardson, Andrea; Birkbak, Nicolai Juul; Eklund, Aron Charles; Downward, Julian; Kschischo, Maik; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Cancer Epidemiology, Biomarkers & Prevention, 22.07.2011, p. 2184-2197.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  29. Published

    A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.. / Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul; Szallasi, Zoltan Imre; Kschischo, Maik; A. Graham, Trevor; Swanton, Charles.

    In: OncoTarget, 2011.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  30. Published

    Chromosomal Instability Confers Intrinsic Multidrug Resistance. / Lee, Alvin J. X.; Endesfelder, David; Rowan, Andrew J.; Walther, Axel; Birkbak, Nicolai Juul; Futreal, P. Andrew; Downward, Julian; Szallasi, Zoltan Imre; Tomlinson, Ian P. M.; Howell, Michael; Kschischo, Maik; Swanton, Charles.

    In: Cancer Research, Vol. 71, No. 5, 2011, p. 1858-1870.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  31. Published

    Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response. / Li, Qiyuan; Eklund, Aron Charles; Birkbak, Nicolai Juul; Desmedt, Christine; Haibe-Kains, Benjamin; Sotiriou, Christos; Symmans, W. Fraser; Pusztai, Lajos; Brunak, Søren; Richardson, Andrea L; Szallasi, Zoltan Imre.

    In: B M C Bioinformatics, Vol. 12, No. 1, 2011, p. 310.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  32. Published

    Jetset: selecting the optimal microarray probe set to represent a gene. / Li, Qiyuan; Birkbak, Nicolai Juul; Gyorffy, Balazs; Szallasi, Zoltan Imre; Eklund, Aron Charles.

    In: B M C Bioinformatics, Vol. 12, No. 1, 2011, p. 474.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  33. Published

    Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer. / Birkbak, Nicolai Juul; Eklund, Aron Charles; Li, Qiyuan; McClelland, Sarah E.; Endesfelder, David; Tan, Patrick; Tan, Iain B.; Richardson, Andrea L.; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Cancer Research, Vol. 71, No. 10, 2011, p. 3447-3452.

    Publication: Research - peer-reviewJournal article – Annual report year: 2011

  34. Published
  35. 2010
  36. Published

    AMOUNT OF ALLELIC IMBALANCE PREDICTS RESPONSE TO CISPLATIN IN BREAST AND OVARIAN CANCER. / Birkbak, Nicolai Juul; Wang, Z.C.; Li, Y.; Wang, Y.; Carlton, V.; Iglehart, J.D.; Garber, J.E.; Silver, D.P.; Szallasi, Z.; Richardson, A.L.

    In: Annals of Oncology, Vol. 21, No. 30-30, 2010, p. 33P.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2010

  37. Published

    Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials. / Juul, Nicolai Stefan; Szallasi, Zoltan Imre; Eklund, Aron Charles; Li, Qiyuan; Burrell, RA; Gerlinger, M; Valero, V; Andreopoulou, E; Esteva, FJ; Symmans, WF; Desmedt, C; Haibe-Kains, B; Sotiriou, C; Pusztai, L; Swanton, C.

    In: Lancet Oncology, Vol. 11, No. 4, 2010, p. 358-365.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  38. Published

    Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer. / Szallasi, Zoltan Imre; Eklund, Aron Charles; Li, Qiyuan; Juul, Nicolai Stefan; Silver, Daniel P.; Richardson, Andrea L.; Wang, Zhigang C.; Leong, Chee-Onn; Calogrias, Diana; Buraimoh, Ayodele; Fatima, Aquila; Gelman, Rebecca S.; Ryan, Paula D.; Tung, Nadine M.; De Nicolo, Arcangela; Ganesan, Shridar; Miron, Alexander; Colin, Christian; Sgroi, Dennis C.; Ellisen, Leif W.; Winer, Eric P.; Garber, Judy E.

    In: Journal of Clinical Oncology, Vol. 28, No. 7, 2010, p. 1145-1153.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  39. Published

    Minimising Immunohistochemical False Negative ER Classification Using a Complementary 23 Gene Expression Signature of ER Status. / Li, Qiyuan; Eklund, Aron Charles; Birkbak, Nicolai Juul; Haibe-Kains, B.; Workman, Christopher; Richardson, A.L.; Szallasi, Zoltan Imre; Swanton, C.

    In: P L o S One, Vol. 5, No. 12, 2010.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  40. Published

    Targeting Chromosomal Instability and Tumour Heterogeneity in HER2-Positive Breast Cancer. / Burrell, Rebecca A.; Birkbak, Nicolai Juul; Johnston, Stephen R.; Reis-Filho, Jorge S.; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Journal of Cellular Biochemistry, Vol. 111, No. 4, 2010, p. 782-790.

    Publication: Research - peer-reviewJournal article – Annual report year: 2010

  41. 2009
  42. Published

    A Functional Metagene Incorporating TTK Protein Kinase, Aurora Kinase B and Glucosylceramide Synthase Predicts Response to Treatment in Primary Breast Cancer. / Juul, Nicolai Stefan; Eklund, Aron Charles; Li, Qiyuan; Downward, J.; Burrell, R.; Szallasi, Zoltan Imre; Swanton, C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 602S-602S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  43. Published

    A Genomic-Profile Derived Summary Measure of Chromosomal Breakpoints Predicts Response to Treatment with the DNA-Damaging Agent Cisplatin.. / Juul, Nicolai Stefan; Wang, Y; Kim, JY; Eklund, Aron Charles; Li, Qiyuan; Carlton, VEH; Gerlinger, M; Swanton, C; Garber, JE; Silver, DP; Faham, M; Richardson, A. L; Szallasi, Zoltan Imre; Wang, Z. C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 509S-510S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  44. Published

    Computational Dissection of Tumor Expression Profiles. / Eklund, Aron Charles; Juul, Nicolai Stefan; Li, Qiyuan; Richardson, A. L; Szallasi, Zoltan Imre.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 591S-591S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  45. Published

    Consistent Principal Components from Triple Negative Breast Cancer Expression Profiles Yields Agent Specific Predictors of Chemotherapy Response. / Li, Qiyuan; Eklund, Aron Charles; Juul, Nicolai Stefan; Desmedt, C; Haibe-Kain, B; Sotiriou, C; Symmans, W. F.; Pusztai, L; Richardson, A. L.; Szallasi, Zoltan Imre.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 700S-700S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

  46. Published
  47. Published

    Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo. / Burrell, R.A.; McClelland, S.E.; Juul, Nicolai Stefan; Downward, J.; Szallasi, Zoltan Imre; Swanton, C.

    In: Cancer Research, Vol. 69, No. 24, 2009, p. 641S-641S.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2009

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