Nicolai Juul Birkbak

  1. 2015
  2. Published

    Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. / McGranahan, Nicholas; Favero, Francesco; de Bruin, Elza C.; Birkbak, Nicolai Juul; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Science Translational Medicine, Vol. 7, No. 283, 283ra54, 2015.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  3. Published

    Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome. / Favero, Francesco; McGranahan, N.; Salm, M.; Birkbak, Nicolai Juul; Sanborn, J. Z.; Benz, S. C.; Becq, J.; Peden, J. F.; Kingsbury, Z.; Grocok, R. J.; Eklund, Aron Charles; Szallasi, Zoltan Imre.

    In: Annals of Oncology, Vol. 26, No. 5, 2015, p. 880-887.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  4. Published

    Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macroevolution of a double minute chromosome.. / Favero, Francesco; McGranahan, Nicholas; Salm, Maximilian P.; Birkbak, Nicolai Juul; Sanborn, J. Zachary ; Benz, Stephen C. ; Becq, Jennifer; Peden, John F. ; Kingsbury, Zoya ; Grocok, Russell J. ; Eklund, Aron Charles.

    In: Annals of Oncology, Vol. 26, No. 5, 2015, p. 880-887.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  5. Published
  6. 2014
  7. Published

    A pan-cancer analysis of inferred homologous recombination deficiency identifies potential platinum benefit in novel subtypes. / Marquard, Andrea Marion; Eklund, Aron Charles; Wang, Zhigang C.; Richardson, Andrea L.; Szallasi, Zoltan Imre; Birkbak, Nicolai Juul.

    In: Cancer Research, Vol. 74, No. 19 - Supplement, 2822, 2014.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2015

  8. Published

    Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?. / Shi, Leming; Haibe-Kains, Benjamin; Birkbak, Nicolai Juul; Bedard, Philippe L.; Hatzis, Christos; Stern, David F.; Clarke, Robert; Quackenbush, John; Beck, Andrew H.; Aerts, Hugo J. W. L.

    In: Cancer Research, Vol. 74, No. 15, 2014, p. 4016-4023.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  9. Published

    Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer.. / Roylance, Rebecca; Endesfelder, David; Jamal-Hanjani, Mariam; Burrell, Rebecca A.; Gorman, Patricia; Sander, Jil; Murphy, Niamh; Birkbak, Nicolai Juul; Hanby, Andrew M.; Speirs, Valerie; Johnston, Stephen R. D.; Kschischo, Maik; Swanton, Charles.

    In: Breast Cancer Research and Treatment, Vol. 148, No. 1, 2014, p. 221-229.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  10. Published

    Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection. / Christensen, Dan Ploug; Gysemans, Conny; Lundh, Morten; Dahllöf, Mattias Salling; Noesgaard, Daniel; Schmidt, Søren Fisker; Mandrup, Susanne; Birkbak, Nicolai Juul; Workman, Christopher; Piemonti, Lorenzo; Blaabjerg, Lykke; Monzani, Valmen; Fossati, Gianluca; Mascagni, Paolo; Paraskevas, Steven; Aikin, Reid A.; Billestrup, Nils; Grunnet, Lars Groth; Dinarello, Charles A.; Mathieu, Chantal; Mandrup-Poulsen, Thomas.

    In: National Academy of Sciences. Proceedings, Vol. 111, No. 3, 2014, p. 1055-1059.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  11. STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes. / Xiang, Michael; Birkbak, Nicolai Juul; Vafaizadeh, Vida; Walker, Sarah R. ; Yeh, Jennifer E. ; Liu, Suhu; Kroll, Yasmin; Boldin, Mark; Taganov, Konstantin; Groner, Bernd; Richardson, Andrea L.; Frank, David A. .

    In: Science Signaling, Vol. 7, No. 310, 2014.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  12. Published

    Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers. / Gulati, Sakshi; Martinez, Pierre; Joshi, Tejal; Birkbak, Nicolai Juul; Santos, Claudio R.; Rowan, Andrew J.; Pickering, Lisa; Gore, Martin; Larkin, James; Szallasi, Zoltan Imre; Bates, Paul A.; Swanton, Charles; Gerlinger, Marco.

    In: European Urology, Vol. 66, No. 5, 2014, p. 936-948.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  13. Published

    Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study. / Jamal-Hanjani, Mariam; Hackshaw, Alan; Ngai, Yenting; Shaw, Jacqueline; Dive, Caroline; Quezada, Sergio; Middleton, Gary; de Bruin, Elza; Le Quesne, John; Shafi, Seema; Falzon, Mary; Horswell, Stuart; Blackhall, Fiona; Khan, Iftekhar; Janes, Sam; Nicolson, Marianne; Lawrence, David; Forster, Martin; Fennell, Dean; Lee, Siow-Ming; Lester, Jason; Kerr, Keith; Muller, Salli; Iles, Natasha; Smith, Sean; Murugaesu, Nirupa; Mitter, Richard; Salm, Max; Stuart, Aengus; Matthews, Nik; Adams, Haydn; Ahmad, Tanya; Attanoos, Richard; Bennett, Jonathan; Birkbak, Nicolai Juul; Booton, Richard; Brady, Ged; Buchan, Keith; Capitano, Arrigo; Chetty, Mahendran; Cobbold, Mark; Crosbie, Philip; Davies, Helen; Denison, Alan; Djearman, Madhav; Goldman, Jacki; Haswell, Tom; Joseph, Leena; Kornaszewska, Malgorzata; Krebs, Matthew; Langman, Gerald; MacKenzie, Mairead; Millar, Joy; Morgan, Bruno; Naidu, Babu; Nonaka, Daisuke; Peggs, Karl; Pritchard, Catrin; Remmen, Hardy; Rowan, Andrew; Shah, Rajesh; Smith, Elaine; Summers, Yvonne; Taylor, Magali; Veeriah, Selvaraju; Waller, David; Wilcox, Ben; Wilcox, Maggie; Woolhouse, Ian; McGranahan, Nicholas; Swanton, Charles.

    In: P L o S Biology, Vol. 12, No. 7, e1001906, 2014.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  14. 2013
  15. Published

    31P gain of chromosomal region 15q26 cause increased expression of blm and fanci, and is associated with sensitivity to platinum chemotherapy in triple negative breast cancer. / Birkbak, Nicolai Juul; Li, Y.; Bowman-Collin, C.; Iglehart, J.D.; Silver, D.; Wang, Z.C.; Szallasi, Zoltan Imre; Richardson, A.

    In: Annals of Oncology, Vol. 24, No. suppl 3, 2013, p. iii22.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  16. Published
  17. Published

    Computational optimisation of targeted DNA sequencing for cancer detection.. / Martinez, Pierre; McGranahan, Nicholas; Birkbak, Nicolai Juul; Gerlinger, Marco; Swanton, Charles.

    In: Scientific Reports, Vol. 3, 2013, p. 3309.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  18. Published

    Exome mutation burden predicts clinical outcome in ovarian cancer carrying mutated BRCA1 and BRCA2 genes. / Birkbak, Nicolai Juul; Kochupurakkal, Bose; Gonzalez-Izarzugaza, Jose Maria; Li, Yang; Liu, Joyce; Szallasi, Zoltan Imre; Matulonis, Ursula; Richardson, Andrea L.; Iglehart, J. Dirk; Wang, Zhigang C.

    In: Cancer Research, Vol. 73, No. S1, 2013.

    Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2014

  19. Published

    HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. / Adelman, Carrie A.; Lolo, Rafal L.; Birkbak, Nicolai Juul; Murina, Olga; Matsuzaki, Kenichiro; Horejsi, Zuzana; Parmar, Kalindi; Borel, Valérie; Skehel, J. Mark; Stamp, Gordon; D'Andrea, Alan; Sartori, Alessandro A; Swanton, Charles; Boulton, Simon J.

    In: Nature, Vol. 502, 2013, p. 381-384.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  20. Published

    Inconsistency in large pharmacogenomic studies. / Haibe-Kains, Benjamin; El-Hachem, Nehme; Birkbak, Nicolai Juul; Jin, Andrew C.; Beck, Andrew H; Aerts, Hugo J. W. L.; Quackenbush, John.

    In: Nature, Vol. 504, No. 7480, 2013, p. 389–393.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  21. Published

    Methods for predicting anti-cancer response. / Szallasi, Zoltan Imre (Inventor); Eklund, Aron Charles (Inventor); Birkbak, Nicolai Juul (Inventor); Richardson, Andrea L. (Inventor); Silver, Daniel P. (Inventor); Wang, Zhigang (Inventor).

    IPC No.: C12Q1/68. Patent No.: WO2013130347. Sep 06, 2013.

    Publication: ResearchPatent – Annual report year: 2012

  22. Published

    Parallel evolution of tumor subclones mimics diversity between tumors. / Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco; McGranahan, Nicholas; Burrell, Rebecca; Rowan, Andrew; Joshi, Tejal; Fisher, Rosalie; Larkin, James; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Journal of Pathology, Vol. 230, No. 4, 2013, p. 356-364.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  23. Published

    Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations. / Birkbak, Nicolai Juul; Kochupurakkal, Bose; Gonzalez-Izarzugaza, Jose Maria; Eklund, Aron Charles; Li, Yang; Liu, Joyce; Szallasi, Zoltan Imre; Matulonis, Ursula A. ; Richardson, Andrea L. ; Iglehart, J. Dirk ; Wang, Zhigang C.

    In: P L o S One, Vol. 8, No. 11, e80023, 2013.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  24. 2012
  25. Published

    CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction. / Lee, Alvin J. X.; Roylance, Rebecca; Sander, Jil; Gorman, Patricia; Endesfelder, David; Kschischo, Maik; Jones, Neil P.; East, Philip; Nicke, Barbara; Spassieva, Stefka; Obeid, Lina M.; Birkbak, Nicolai Juul; Szallasi, Zoltan; McKnight, Nicole C.; Rowan, Andrew J.; Speirs, Valerie; Hanby, Andrew M.; Downward, Julian; Tooze, Sharon A.; Swanton, Charles.

    In: Journal of Pathology, Vol. 226, No. 3, 2012, p. 482-494.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  26. Published

    Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome. / Wang, Zhigang C.; Birkbak, Nicolai Juul; Culhane, Aedín C.; Drapkin, Ronny; Fatima, Aquila; Tian, Ruiyang; Schwede, Matthew; Alsop, Kathryn; Daniels, Kathryn E.; Piao, Huiying; Liu, Joyce; Etemadmoghadam, Dariush; Miron, Alexander; Salvesen, Helga B.; Mitchell, Gillian; DeFazio, Anna; Quackenbush, John; Berkowitz, Ross S.; Iglehart, J. Dirk; Bowtell, David D.L.; Matulonis, Ursula A.

    In: Clinical Cancer Research, Vol. 18, No. 20, 2012, p. 5806-5815.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  27. Published

    Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents. / Birkbak, Nicolai J.; Wang, Zhigang C.; Kim, Ji-Young; Eklund, Aron C.; Li, Qiyuan; Tian, Ruiyang; Bowman-Colin, Christian; Li, Yang; Greene-Colozzi, April; Iglehart, J. Dirk; Tung, Nadine; Ryan, Paula D.; Garber, Judy E.; Silver, Daniel P.; Szallasi, Zoltan; Richardson, Andrea L.

    In: Cancer Drug Discovery and Development, Vol. 2, No. 4, 2012, p. 366-375.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  28. 2011
  29. Published

    Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer. / Roylance, Rebecca; Endesfelder, David; Gorman, Patricia; Sander, Jil; Tomlinson, Ian; M. Hanby, Andrew; Speirs, Valerie; L. Richardson, Andrea; Birkbak, Nicolai Juul; Eklund, Aron Charles; Downward, Julian; Kschischo, Maik; Szallasi, Zoltan Imre; Swanton, Charles.

    In: Cancer Epidemiology, Biomarkers & Prevention, 22.07.2011, p. 2184-2197.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

  30. Published

    A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.. / Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul; Szallasi, Zoltan Imre; Kschischo, Maik; A. Graham, Trevor; Swanton, Charles.

    In: OncoTarget, 2011.

    Publication: Research - peer-reviewJournal article – Annual report year: 2012

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